A Simple and Computationally Efficient Approach to Multifactor Dimensionality Reduction Analysis of Gene-Gene Interactions for Quantitative Traits

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Gui, Jiang; Moore, Jason H.; Williams, Scott M.; Andrews, Peter; Hillege, Hans L.; van der Harst, Pim; Navis, Gerjan; Van Gilst, Wiek H.; Asselbergs, Folkert W.; Gilbert-Diamond, Diane;
(2013)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 8,issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3689797, doi: 10.1371/journal.pone.0066545
  • Subject: Computational Biology | Algorithms | SUSCEPTIBILITY | Research Article | Mathematics | Epigenetics | Epidemiology | Genetics | RENIN-ANGIOTENSIN | Gene Networks | Computer Science | SYSTEMS | Genome Analysis Tools | Genomics | Biostatistics | Population Genetics | DISEASE | Biology | Genetics of Disease | EPISTASIS | Genetic Networks | Clinical Research Design | BRADYKININ | Medicine | PLASMA T-PA | POLYMORPHISMS | POPULATION | Cardiovascular Disease Epidemiology | Q | R | Science | Prospective Studies | Clinical Epidemiology | PENALIZED LOGISTIC-REGRESSION | Genetic Polymorphism | Statistics

We present an extension of the two-class multifactor dimensionality reduction (MDR) algorithm that enables detection and characterization of epistatic SNP-SNP interactions in the context of a quantitative trait. The proposed Quantitative MDR (QMDR) method handles contin... View more