Therapeutic Potential of the Translation Inhibitor Silvestrol in Hepatocellular Cancer

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Takayuki Kogure; A Douglas Kinghorn; Irene Yan; Brad Bolon; David M Lucas; Michael R Grever; Tushar Patel;

Background & Aims Although hepatocellular cancers (HCC) frequently arise in the setting of fibrosis and a hepatic regenerative response requiring new cell growth, therapeutic strategies for these cancers have not targeted protein synthesis. Silvestrol, a rocaglate isola... View more