publication . Article . 2015

Sharing big biomedical data

Toga, Arthur W; Dinov, Ivo D;
Open Access English
  • Published: 01 Jun 2015 Journal: Journal of Big Data, volume 2, issue 1 (issn: 2196-1115, eissn: 2196-1115, Copyright policy)
  • Publisher: Springer International Publishing
Abstract
Background The promise of Big Biomedical Data may be offset by the enormous challenges in handling, analyzing, and sharing it. In this paper, we provide a framework for developing practical and reasonable data sharing policies that incorporate the sociological, financial, technical and scientific requirements of a sustainable Big Data dependent scientific community. Findings Many biomedical and healthcare studies may be significantly impacted by using large, heterogeneous and incongruent datasets; however there are significant technical, social, regulatory, and institutional barriers that need to be overcome to ensure the power of Big Data overcomes these detrim...
Subjects
free text keywords: Analytics, Privacy, Short Report, Big data, Sharing, Policy
Funded by
NIH| Big Data for Discovery Science
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3U54EB020406-03S1
  • Funding stream: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
,
NIH| Laboratory of Neuro Imaging Resource (LONIR)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 7P41EB015922-17
  • Funding stream: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
65 references, page 1 of 5

1. ENCODE Project Consortium (2004) The ENCODE (ENCyclopedia of DNA elements) project. Science 306(5696):636-640

2. Kolker E, Higdon R, Haynes W, Welch D, Broomall W, Lancet D, Stanberry L, Kolker N (2012) MOPED: model organism protein expression database. Nucleic Acids Res 40(D1):D1093-D1099 [OpenAIRE]

3. Jack C, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, L Whitwell J, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, DeCarli CS, Krueger G, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M et al (2008) The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods. J Magn Reson Imaging 27(4):685-691

4. Verma M, Wright GL Jr, Hanash SM, Gopal-Srivastava R, Srivastava S (2001) Proteomic approaches within the NCI early detection research network for the discovery and identification of cancer biomarkers. Ann N Y Acad Sci 945(1):103-115

5. Parkinson Progression Marker Initiative (2011) The Parkinson Progression Marker Initiative (PPMI). Prog Neurobiol 95(4):629-635

6. Mailman MD, Feolo M, Jin Y, Kimura M, Tryka K, Bagoutdinov R, Hao L, Kiang A, Paschall J, Phan L, Popova N, Pretel S, Ziyabari L, Lee M, Shao Y, Wang ZY, Sirotkin K, Ward M, Kholodov M, Zbicz K, Beck J, Kimelman M, Shevelev S, Preuss D, Yaschenko E, Graeff A, Ostell J, Sherry ST (2007) The NCBI dbGaP database of genotypes and phenotypes. Nat Genet 39(10):1181-1186

7. Califf RM, Zarin DA, Kramer JM, Sherman RE, Aberle LH, Tasneem A (2012) Characteristics of clinical trials registered in ClinicalTrials. gov, 2007-2010. JAMA 307(17):1838-1847

8. Ross JS, Tse T, Zarin DA, Xu H, Zhou L, Krumholz HM (2012) Publication of NIH funded trials registered in ClinicalTrials. gov: cross sectional analysis. BMJ 344:d7292, http://www.bmj.com/content/344/bmj.d7292

9. Birney E (2012) The making of ENCODE: lessons for big-data projects. Nature 489(7414):49-51

10. Gerstein M (2012) Genomics: ENCODE leads the way on big data. Nature 489(7415):208

11. Ohno-Machado L (2012) Big science, big data, and a big role for biomedical informatics. J Am Med Inform Assoc 19(1e), e1

12. Shah NH (2012) Translational bioinformatics embraces big data. Yearb Med Inform 7(1):130-134

13. Shah NH, Tenenbaum JD (2012) The coming age of data-driven medicine: translational bioinformatics' next frontier. J Am Med Inform Assoc 19(e1):e2-e4 [OpenAIRE]

14. Toga AW (2012) The clinical value of large neuroimaging data sets in Alzheimer's disease. Neuroimaging Clin N Am 22(1):107-118

15. Toga AW, Crawford KL, Alzheimer's Disease Neuroimaging (2010) The informatics core of the Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement 6(3):247-256

65 references, page 1 of 5
Abstract
Background The promise of Big Biomedical Data may be offset by the enormous challenges in handling, analyzing, and sharing it. In this paper, we provide a framework for developing practical and reasonable data sharing policies that incorporate the sociological, financial, technical and scientific requirements of a sustainable Big Data dependent scientific community. Findings Many biomedical and healthcare studies may be significantly impacted by using large, heterogeneous and incongruent datasets; however there are significant technical, social, regulatory, and institutional barriers that need to be overcome to ensure the power of Big Data overcomes these detrim...
Subjects
free text keywords: Analytics, Privacy, Short Report, Big data, Sharing, Policy
Funded by
NIH| Big Data for Discovery Science
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3U54EB020406-03S1
  • Funding stream: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
,
NIH| Laboratory of Neuro Imaging Resource (LONIR)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 7P41EB015922-17
  • Funding stream: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
65 references, page 1 of 5

1. ENCODE Project Consortium (2004) The ENCODE (ENCyclopedia of DNA elements) project. Science 306(5696):636-640

2. Kolker E, Higdon R, Haynes W, Welch D, Broomall W, Lancet D, Stanberry L, Kolker N (2012) MOPED: model organism protein expression database. Nucleic Acids Res 40(D1):D1093-D1099 [OpenAIRE]

3. Jack C, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, L Whitwell J, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, DeCarli CS, Krueger G, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M et al (2008) The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods. J Magn Reson Imaging 27(4):685-691

4. Verma M, Wright GL Jr, Hanash SM, Gopal-Srivastava R, Srivastava S (2001) Proteomic approaches within the NCI early detection research network for the discovery and identification of cancer biomarkers. Ann N Y Acad Sci 945(1):103-115

5. Parkinson Progression Marker Initiative (2011) The Parkinson Progression Marker Initiative (PPMI). Prog Neurobiol 95(4):629-635

6. Mailman MD, Feolo M, Jin Y, Kimura M, Tryka K, Bagoutdinov R, Hao L, Kiang A, Paschall J, Phan L, Popova N, Pretel S, Ziyabari L, Lee M, Shao Y, Wang ZY, Sirotkin K, Ward M, Kholodov M, Zbicz K, Beck J, Kimelman M, Shevelev S, Preuss D, Yaschenko E, Graeff A, Ostell J, Sherry ST (2007) The NCBI dbGaP database of genotypes and phenotypes. Nat Genet 39(10):1181-1186

7. Califf RM, Zarin DA, Kramer JM, Sherman RE, Aberle LH, Tasneem A (2012) Characteristics of clinical trials registered in ClinicalTrials. gov, 2007-2010. JAMA 307(17):1838-1847

8. Ross JS, Tse T, Zarin DA, Xu H, Zhou L, Krumholz HM (2012) Publication of NIH funded trials registered in ClinicalTrials. gov: cross sectional analysis. BMJ 344:d7292, http://www.bmj.com/content/344/bmj.d7292

9. Birney E (2012) The making of ENCODE: lessons for big-data projects. Nature 489(7414):49-51

10. Gerstein M (2012) Genomics: ENCODE leads the way on big data. Nature 489(7415):208

11. Ohno-Machado L (2012) Big science, big data, and a big role for biomedical informatics. J Am Med Inform Assoc 19(1e), e1

12. Shah NH (2012) Translational bioinformatics embraces big data. Yearb Med Inform 7(1):130-134

13. Shah NH, Tenenbaum JD (2012) The coming age of data-driven medicine: translational bioinformatics' next frontier. J Am Med Inform Assoc 19(e1):e2-e4 [OpenAIRE]

14. Toga AW (2012) The clinical value of large neuroimaging data sets in Alzheimer's disease. Neuroimaging Clin N Am 22(1):107-118

15. Toga AW, Crawford KL, Alzheimer's Disease Neuroimaging (2010) The informatics core of the Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement 6(3):247-256

65 references, page 1 of 5
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publication . Article . 2015

Sharing big biomedical data

Toga, Arthur W; Dinov, Ivo D;