Phospholipase A2 – nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment

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Hermann, Petra M.; Watson, Shawn N.; Wildering, Willem C.;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Genetics,volume 5 (issn: 1664-8021, eissn: 1664-8021)
  • Related identifiers: doi: 10.3389/fgene.2014.00419/full, doi: 10.3389/fgene.2014.00419, pmc: PMC4255604
  • Subject: neuronal plasticity | Spike frequency adaptation | QH426-470 | Review Article | Genetics | phospholipases A2 | Gastropoda | age-associated memory impairment (AMI) | aging | Lymnaea stagnalis | lipid peroxidation | neuronal excitability

TThe aging brain can undergo a range of changes varying from subtle structural and physiological changes causing only minor functional decline under healthy normal aging conditions, to severe cognitive or neurological impairment associated with extensive loss of neurons... View more
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