publication . Article . 2017

Photoluminescent Gold Nanoclusters in Cancer Cells: Cellular Uptake, Toxicity, and Generation of Reactive Oxygen Species

Matulionyte, Marija; Dapkute, Dominyka; Budenaite, Laima; Jarockyte, Greta; Rotomskis, Ricardas;
Open Access English
  • Published: 01 Feb 2017 Journal: International Journal of Molecular Sciences, volume 18, issue 2 (issn: 1422-0067, eissn: 1422-0067, Copyright policy)
  • Publisher: MDPI AG
Abstract
In recent years, photoluminescent gold nanoclusters have attracted considerable interest in both fundamental biomedical research and practical applications. Due to their ultrasmall size, unique molecule-like optical properties, and facile synthesis gold nanoclusters have been considered very promising photoluminescent agents for biosensing, bioimaging, and targeted therapy. Yet, interaction of such ultra-small nanoclusters with cells and other biological objects remains poorly understood. Therefore, the assessment of the biocompatibility and potential toxicity of gold nanoclusters is of major importance before their clinical application. In this study, the cellu...
Subjects
mesheuropmc: mental disorders
free text keywords: toxicity, Chemistry, breast cancer cells, photoluminescence, accumulation, QD1-999, gold nanoclusters, reactive oxygen species, Article, Biology (General), QH301-705.5
71 references, page 1 of 5

Liu, J.L., Lu, L.L., Xu, S.Y., Wang, L.Y.. One-pot synthesis of gold nanoclusters with bright red fluorescence and good biorecognition abilities for visualization fluorescence enhancement detection of E. coli. Talanta. 2015; 134: 54-59 [PubMed] [DOI]

Chen, T.H., Tseng, W.L.. (Lysozyme type VI)-stabilized Au8 clusters: Synthesis mechanism and application for sensing of glutathione in a single drop of blood. Small. 2012; 8: 1912-1919 [PubMed] [DOI]

Chen, L.Y., Wang, C.W., Yuan, Z.Q., Chang, H.T.. Fluorescent gold nanoclusters: Recent advances in sensing and imaging. Anal. Chem.. 2015; 87: 216-229 [PubMed] [DOI]

Shang, L., Stockmar, F., Azadfar, N., Nienhaus, G.U.. Intracellular thermometry by using fluorescent gold nanoclusters. Angew. Chem. Int. Edit.. 2013; 52: 11154-11157 [PubMed] [DOI]

Chen, D.Y., Luo, Z.T., Li, N.J., Lee, J.Y., Xie, J.P., Lu, J.M.. Amphiphilic polymeric nanocarriers with luminescent gold nanoclusters for concurrent bioimaging and controlled drug release. Adv. Funct. Mater.. 2013; 23: 4324-4331 [DOI]

Chen, H.Y., Li, B.W., Ren, X.Y., Li, S.N., Ma, Y.X., Cui, S.S., Gu, Y.Q.. Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy. Biomaterials. 2012; 33: 8461-8476 [PubMed] [DOI]

Wang, Y.L., Chen, J.J., Irudayaraj, J.. Nuclear targeting dynamics of gold nanoclusters for enhanced therapy of HER2+ breast cancer. ACS Nano. 2011; 5: 9718-9725 [PubMed] [DOI]

Zhang, X.-D., Luo, Z., Chen, J., Shen, X., Song, S., Sun, Y., Fan, S., Fan, F., Leong, D.T., Xie, J.. Ultrasmall Au10−12(SG)10−12 nanomolecules for high tumor specificity and cancer radiotherapy. Adv. Mater.. 2014; 26: 4565-4568 [OpenAIRE] [PubMed] [DOI]

Kubo, R.. Electronic properties of metallic fine particles. J. Phys. Soc. Jpn.. 1962; 17: 975-986 [DOI]

Haberland, H.. Clusters of Atoms and Molecules: Theory Experiment, and Clusters of Atoms. 1994

Schaaff, T.G., Knight, G., Shafigullin, M.N., Borkman, R.F., Whetten, R.L.. Isolation and selected properties of a 10.4 kDa gold: Glutathione cluster compound. J. Phys. Chem. B. 1998; 102: 10643-10646 [DOI]

Haiss, W., Thanh, N.T.K., Aveyard, J., Fernig, D.G.. Determination of size and concentration of gold nanoparticles from UV-Vis spectra. Anal. Chem.. 2007; 79: 4215-4221 [PubMed] [DOI]

Zheng, J., Zhang, C.W., Dickson, R.M.. Highly fluorescent, water-soluble, size-tunable gold quantum dots. Phys. Rev. Lett.. 2004; 93: 077402 [PubMed] [DOI]

Jin, R.C.. Atomically precise metal nanoclusters: Stable sizes and optical properties. Nanoscale. 2015; 7: 1549-1565 [PubMed] [DOI]

Yang, H.Y., Wang, Y., Huang, H.Q., Gell, L., Lehtovaara, L., Malola, S., Hakkinen, H., Zheng, N.F.. All-thiol-stabilized Ag44 and Au12Ag32 nanoparticles with single-crystal structures. Nat. Commun.. 2013; 4: 2422 [OpenAIRE] [PubMed] [DOI]

71 references, page 1 of 5
Abstract
In recent years, photoluminescent gold nanoclusters have attracted considerable interest in both fundamental biomedical research and practical applications. Due to their ultrasmall size, unique molecule-like optical properties, and facile synthesis gold nanoclusters have been considered very promising photoluminescent agents for biosensing, bioimaging, and targeted therapy. Yet, interaction of such ultra-small nanoclusters with cells and other biological objects remains poorly understood. Therefore, the assessment of the biocompatibility and potential toxicity of gold nanoclusters is of major importance before their clinical application. In this study, the cellu...
Subjects
mesheuropmc: mental disorders
free text keywords: toxicity, Chemistry, breast cancer cells, photoluminescence, accumulation, QD1-999, gold nanoclusters, reactive oxygen species, Article, Biology (General), QH301-705.5
71 references, page 1 of 5

Liu, J.L., Lu, L.L., Xu, S.Y., Wang, L.Y.. One-pot synthesis of gold nanoclusters with bright red fluorescence and good biorecognition abilities for visualization fluorescence enhancement detection of E. coli. Talanta. 2015; 134: 54-59 [PubMed] [DOI]

Chen, T.H., Tseng, W.L.. (Lysozyme type VI)-stabilized Au8 clusters: Synthesis mechanism and application for sensing of glutathione in a single drop of blood. Small. 2012; 8: 1912-1919 [PubMed] [DOI]

Chen, L.Y., Wang, C.W., Yuan, Z.Q., Chang, H.T.. Fluorescent gold nanoclusters: Recent advances in sensing and imaging. Anal. Chem.. 2015; 87: 216-229 [PubMed] [DOI]

Shang, L., Stockmar, F., Azadfar, N., Nienhaus, G.U.. Intracellular thermometry by using fluorescent gold nanoclusters. Angew. Chem. Int. Edit.. 2013; 52: 11154-11157 [PubMed] [DOI]

Chen, D.Y., Luo, Z.T., Li, N.J., Lee, J.Y., Xie, J.P., Lu, J.M.. Amphiphilic polymeric nanocarriers with luminescent gold nanoclusters for concurrent bioimaging and controlled drug release. Adv. Funct. Mater.. 2013; 23: 4324-4331 [DOI]

Chen, H.Y., Li, B.W., Ren, X.Y., Li, S.N., Ma, Y.X., Cui, S.S., Gu, Y.Q.. Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy. Biomaterials. 2012; 33: 8461-8476 [PubMed] [DOI]

Wang, Y.L., Chen, J.J., Irudayaraj, J.. Nuclear targeting dynamics of gold nanoclusters for enhanced therapy of HER2+ breast cancer. ACS Nano. 2011; 5: 9718-9725 [PubMed] [DOI]

Zhang, X.-D., Luo, Z., Chen, J., Shen, X., Song, S., Sun, Y., Fan, S., Fan, F., Leong, D.T., Xie, J.. Ultrasmall Au10−12(SG)10−12 nanomolecules for high tumor specificity and cancer radiotherapy. Adv. Mater.. 2014; 26: 4565-4568 [OpenAIRE] [PubMed] [DOI]

Kubo, R.. Electronic properties of metallic fine particles. J. Phys. Soc. Jpn.. 1962; 17: 975-986 [DOI]

Haberland, H.. Clusters of Atoms and Molecules: Theory Experiment, and Clusters of Atoms. 1994

Schaaff, T.G., Knight, G., Shafigullin, M.N., Borkman, R.F., Whetten, R.L.. Isolation and selected properties of a 10.4 kDa gold: Glutathione cluster compound. J. Phys. Chem. B. 1998; 102: 10643-10646 [DOI]

Haiss, W., Thanh, N.T.K., Aveyard, J., Fernig, D.G.. Determination of size and concentration of gold nanoparticles from UV-Vis spectra. Anal. Chem.. 2007; 79: 4215-4221 [PubMed] [DOI]

Zheng, J., Zhang, C.W., Dickson, R.M.. Highly fluorescent, water-soluble, size-tunable gold quantum dots. Phys. Rev. Lett.. 2004; 93: 077402 [PubMed] [DOI]

Jin, R.C.. Atomically precise metal nanoclusters: Stable sizes and optical properties. Nanoscale. 2015; 7: 1549-1565 [PubMed] [DOI]

Yang, H.Y., Wang, Y., Huang, H.Q., Gell, L., Lehtovaara, L., Malola, S., Hakkinen, H., Zheng, N.F.. All-thiol-stabilized Ag44 and Au12Ag32 nanoparticles with single-crystal structures. Nat. Commun.. 2013; 4: 2422 [OpenAIRE] [PubMed] [DOI]

71 references, page 1 of 5
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publication . Article . 2017

Photoluminescent Gold Nanoclusters in Cancer Cells: Cellular Uptake, Toxicity, and Generation of Reactive Oxygen Species

Matulionyte, Marija; Dapkute, Dominyka; Budenaite, Laima; Jarockyte, Greta; Rotomskis, Ricardas;