Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites

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Alfred Amambua-Ngwa; Kevin K A Tetteh; Magnus Manske; Natalia Gomez-Escobar; Lindsay B Stewart; M Elizabeth Deerhake; Ian H Cheeseman; Christopher I Newbold; Anthony A Holder; Ellen Knuepfer; Omar Janha; Muminatou Jallow; Susana Campino; Bronwyn Macinnis; Dominic P Kwiatkowski; David J Conway;
  • Publisher: Public Library of Science
  • Journal: PLoS Genetics,volume 8,issue 11 (issn: 1553-7390, eissn: 1553-7404)
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  • Related identifiers: pmc: PMC3486833, doi: 10.1371/journal.pgen.1002992
  • Subject: Host-Pathogen Interaction | Population Genetics | Research Article | Biology | Natural Selection | Infectious Diseases | Microbiology | Medicine | Immunity | Malaria | Adaptive Immunity | QH426-470 | Genetics | Evolutionary Biology | Plasmodium Falciparum | Genomics | Genome Sequencing | Protozoan Infections | Genetic Polymorphism | Immunology | Parasite Evolution | Parasitology
    mesheuropmc: parasitic diseases

Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiable signatures of balancing selection. To comprehensively survey for genes under such selection in the human malaria parasite Plasmodium falciparum, we generated paired-en... View more