publication . Article . 2018

Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy

Kevin C. Oeffinger; Emily S. Tonorezos; Emily S. Tonorezos; Amber Khan; Darren R. Feldman; Darren R. Feldman; Amy Budnick; Dana Barnea;
Open Access
  • Published: 01 May 2018 Journal: Children, volume 5, page 59 (eissn: 2227-9067, Copyright policy)
  • Publisher: MDPI AG
Abstract
The ototoxic effects of radiotherapy have been poorly characterized. We examined adult survivors of childhood cancer who were treated with radiotherapy, which included the head, before the age of 22 years and between 1952 and 2016. Those who received platinum chemotherapy were excluded. Demographic, diagnosis, and treatment outcomes were captured. Audiograms were graded using the Chang and International Society of Paediatric Oncology ototoxicity (SIOP) scales. Among 276 patients with a history of radiation to sites that included the brain, orbit, nasopharynx, and total body irradiation, the median age at treatment was 10.1 years and 59% were male. Of 51 survivor...
Subjects
Medical Subject Headings: otorhinolaryngologic diseases
free text keywords: Article, radiotherapy, survivorship, hearing aids, RJ1-570, Radiation therapy, medicine.medical_treatment, medicine, Psychological intervention, Total body irradiation, Pediatrics, medicine.medical_specialty, Pediatric cancer, Acquired immunodeficiency syndrome (AIDS), medicine.disease, Audiogram, business.industry, business, Hearing loss, medicine.symptom, Ototoxicity
Funded by
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| CANCER EDUCATION PROGRAM
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2R25CA020449-14
  • Funding stream: NATIONAL CANCER INSTITUTE
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