Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction

Article, Other literature type English OPEN
Takayama, Kazuo; Inamura, Mitsuru; Kawabata, Kenji; Katayama, Kazufumi; Higuchi, Maiko; Tashiro, Katsuhisa; Nonaka, Aki; Sakurai, Fuminori; Hayakawa, Takao; Kusuda Furue, Miho; Mizuguchi, Hiroyuki;
(2011)
  • Publisher: Nature Publishing Group
  • Journal: Molecular Therapy,volume 20,issue 1,pages127-137 (issn: 1525-0016)
  • Related identifiers: pmc: PMC3255576, doi: 10.1038/mt.2011.234
  • Subject: Molecular Biology | Original Article | Genetics | Drug Discovery | Pharmacology | Molecular Medicine
    mesheuropmc: embryonic structures

Hepatocyte-like cells from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are expected to be a useful source of cells drug discovery. Although we recently reported that hepatic commitment is promoted by transduction of SOX17 and HEX into hu... View more
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