Beta-adrenergic receptor 1 selective antagonism inhibits norepinephrine-mediated TNF-alpha downregulation in experimental liver cirrhosis.

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Zapater, Pedro; Gómez-Hurtado, Isabel; Peiró, Gloria; González-Navajas, José Manuel; García, Irma; Giménez, Paula; Moratalla, Alba; Such, José; Francés, Rubén;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 7,issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0043371, pmc: PMC3423372
  • Subject: Research Article | Biology | Molecular Cell Biology | Immune Physiology | Signal Transduction | Gastroenterology and Hepatology | Adrenergic Signal Transduction | Medicine | Immunity | Anatomy and Physiology | Q | R | Signaling Pathways | Inflammation | Clinical Immunology | Science | Immune System | Cytokines | Liver Diseases | Immunology | Cirrhosis

BACKGROUND: Bacterial translocation is a frequent event in cirrhosis leading to an increased inflammatory response. Splanchnic adrenergic system hyperactivation has been related with increased bacterial translocation. We aim at evaluating the interacting mechanism betwe... View more
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