GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism

Article English OPEN
Lin, Hua V.; Efanov, Alexander M.; Fang, Xiankang; Beavers, Lisa S.; Wang, Xuesong; Wang, Jingru; Gonzalez Valcarcel, Isabel C.; Ma, Tianwei;
(2016)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 11,issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0157298, pmc: PMC4920590
  • Subject: Research Article | Insulin | Hormones | Anatomy | Pharmacologic-Based Diagnostics | Chemical Compounds | Physical Sciences | Blood Plasma | Organic Chemistry | Endocrine Physiology | Pharmacology | Diet | Chemistry | Carbohydrates | Glucose | Biology and Life Sciences | Physiology | Medicine | Insulin Secretion | Body Fluids | Blood | Q | R | Hematology | Nutrition | Science | Biochemistry | Oral Glucose Suppression Test | Monosaccharides | Medicine and Health Sciences | Organic Compounds | Diabetic Endocrinology | Endocrinology

GPR142, a putative amino acid receptor, is expressed in pancreatic islets and the gastrointestinal tract, but the ligand affinity and physiological role of this receptor remain obscure. In this study, we show that in addition to L-Tryptophan, GPR142 signaling is also ac... View more
Share - Bookmark