Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis

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Plo, Isabelle ; Bellanné-Chantelot, Christine ; Mosca, Matthieu ; Mazzi, Stefania ; Marty, Caroline ; Vainchenker, William (2017)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Endocrinology, volume 8 (issn: 1664-2392, eissn: 1664-2392)
  • Related identifiers: pmc: PMC5600916, doi: 10.3389/fendo.2017.00234
  • Subject: thrombocytosis | thrombopoietin | MPLR102P | thrombocytopenia | Review | MPL | Endocrinology | JAK2
    mesheuropmc: food and beverages | embryonic structures | hemic and immune systems

Megakaryopoiesis is an original and complex cell process which leads to the formation of platelets. The homeostatic production of platelets is mainly regulated and controlled by thrombopoietin (TPO) and the TPO receptor (MPL)/JAK2 axis. Therefore, any hereditary or acqu... View more
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