publication . Article . 2016

Spinal neurons that contain gastrin-releasing peptide seldom express Fos or phosphorylate extracellular signal-regulated kinases in response to intradermal chloroquine

Bell, Andrew M.; Gutierrez-Mecinas, Maria; Polgár, Erika; Todd, Andrew J.;
Open Access English
  • Published: 01 Jun 2016 Journal: Molecular Pain, volume 12 (eissn: 1744-8069, Copyright policy)
  • Publisher: Sage
Abstract
Background: Gastrin-releasing peptide (GRP) is thought to play a role in the itch evoked by intradermal injection of chloroquine. Although some early studies suggested that GRP was expressed in pruriceptive primary afferents, it is now thought that GRP in the spinal cord is derived mainly from a population of excitatory interneurons in lamina II, and it has been suggested that these are involved in the itch pathway. To test this hypothesis, we used the transcription factor Fos and phosphorylation of extracellular signal-regulated kinases (ERK) to look for evidence that interneurons expressing GRP were activated following intradermal injection of chloroquine into...
Subjects
mesheuropmc: hormones, hormone substitutes, and hormone antagonists
free text keywords: Itch, Research Article, interneuron, pERK, spinal cord
54 references, page 1 of 4

1 Bautista DM Wilson SR Hoon MA Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci 2014; 17: 175–182.24473265 [OpenAIRE] [PubMed]

2 LaMotte RH Dong X Ringkamp M Sensory neurons and circuits mediating itch. Nat Rev Neurosci 2014; 15: 19–31.24356071 [OpenAIRE] [PubMed]

3 Ross SE Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease. Curr Opin Neurobiol 2011; 21: 880–887.22054924 [PubMed]

4 Akiyama T Carstens E Neural processing of itch. Neuroscience 2013; 250: 697–714.23891755 [OpenAIRE] [PubMed]

5 Davidson S Zhang X Yoon CH The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci 2007; 27: 10007–10014.17855615 [OpenAIRE] [PubMed]

6 Moser HR Giesler GJ Jr Characterization of pruriceptive trigeminothalamic tract neurons in rats. J Neurophysiol 2014; 111: 1574–1589.24478156 [OpenAIRE] [PubMed]

7 Roberson DP Gudes S Sprague JM Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci 2013; 16: 910–918.23685721 [OpenAIRE] [PubMed]

8 Sun YG Chen ZF A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 2007; 448: 700–703.17653196 [PubMed]

9 Sun YG Zhao ZQ Meng XL Cellular basis of itch sensation. Science 2009; 325: 1531–1534.19661382 [OpenAIRE] [PubMed]

10 Akiyama T Tominaga M Takamori K Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch. Pain 2014; 155: 80–92.24041961 [OpenAIRE] [PubMed]

11 Zhao ZQ Huo FQ Jeffry J Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest 2013; 123: 4769–4780.24216512 [OpenAIRE] [PubMed]

12 Liu XY Wan L Huo FQ B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway. Mol Pain 2014; 10: 4.24438367 [OpenAIRE] [PubMed]

13 Takanami K Sakamoto H Matsuda KI Distribution of gastrin-releasing peptide in the rat trigeminal and spinal somatosensory systems. J Comp Neurol 2014; 522: 1858–1873.24254931 [PubMed]

14 Solorzano C Villafuerte D Meda K Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J Neurosci 2015; 35: 648–657.25589759 [OpenAIRE] [PubMed]

15 Fleming MS Ramos D Han SB The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Mol Pain 2012; 8: 52.22776446 [OpenAIRE] [PubMed]

54 references, page 1 of 4
Abstract
Background: Gastrin-releasing peptide (GRP) is thought to play a role in the itch evoked by intradermal injection of chloroquine. Although some early studies suggested that GRP was expressed in pruriceptive primary afferents, it is now thought that GRP in the spinal cord is derived mainly from a population of excitatory interneurons in lamina II, and it has been suggested that these are involved in the itch pathway. To test this hypothesis, we used the transcription factor Fos and phosphorylation of extracellular signal-regulated kinases (ERK) to look for evidence that interneurons expressing GRP were activated following intradermal injection of chloroquine into...
Subjects
mesheuropmc: hormones, hormone substitutes, and hormone antagonists
free text keywords: Itch, Research Article, interneuron, pERK, spinal cord
54 references, page 1 of 4

1 Bautista DM Wilson SR Hoon MA Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci 2014; 17: 175–182.24473265 [OpenAIRE] [PubMed]

2 LaMotte RH Dong X Ringkamp M Sensory neurons and circuits mediating itch. Nat Rev Neurosci 2014; 15: 19–31.24356071 [OpenAIRE] [PubMed]

3 Ross SE Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease. Curr Opin Neurobiol 2011; 21: 880–887.22054924 [PubMed]

4 Akiyama T Carstens E Neural processing of itch. Neuroscience 2013; 250: 697–714.23891755 [OpenAIRE] [PubMed]

5 Davidson S Zhang X Yoon CH The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci 2007; 27: 10007–10014.17855615 [OpenAIRE] [PubMed]

6 Moser HR Giesler GJ Jr Characterization of pruriceptive trigeminothalamic tract neurons in rats. J Neurophysiol 2014; 111: 1574–1589.24478156 [OpenAIRE] [PubMed]

7 Roberson DP Gudes S Sprague JM Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci 2013; 16: 910–918.23685721 [OpenAIRE] [PubMed]

8 Sun YG Chen ZF A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 2007; 448: 700–703.17653196 [PubMed]

9 Sun YG Zhao ZQ Meng XL Cellular basis of itch sensation. Science 2009; 325: 1531–1534.19661382 [OpenAIRE] [PubMed]

10 Akiyama T Tominaga M Takamori K Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch. Pain 2014; 155: 80–92.24041961 [OpenAIRE] [PubMed]

11 Zhao ZQ Huo FQ Jeffry J Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest 2013; 123: 4769–4780.24216512 [OpenAIRE] [PubMed]

12 Liu XY Wan L Huo FQ B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway. Mol Pain 2014; 10: 4.24438367 [OpenAIRE] [PubMed]

13 Takanami K Sakamoto H Matsuda KI Distribution of gastrin-releasing peptide in the rat trigeminal and spinal somatosensory systems. J Comp Neurol 2014; 522: 1858–1873.24254931 [PubMed]

14 Solorzano C Villafuerte D Meda K Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J Neurosci 2015; 35: 648–657.25589759 [OpenAIRE] [PubMed]

15 Fleming MS Ramos D Han SB The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Mol Pain 2012; 8: 52.22776446 [OpenAIRE] [PubMed]

54 references, page 1 of 4
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publication . Article . 2016

Spinal neurons that contain gastrin-releasing peptide seldom express Fos or phosphorylate extracellular signal-regulated kinases in response to intradermal chloroquine

Bell, Andrew M.; Gutierrez-Mecinas, Maria; Polgár, Erika; Todd, Andrew J.;