RNAi down-regulation of cinnamate-4-hydroxylase increases artemisinin biosynthesis in Artemisia annua

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Ritesh Kumar; Divya Vashisth; Amita Misra; Md Qussen Akhtar; Syed Uzma Jalil; Karuna Shanker; Madan Mohan Gupta; Prashant Kumar Rout; Anil Kumar Gupta; Ajit Kumar Shasany;
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports,volume 6 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: pmc: PMC4879530, doi: 10.1038/srep26458
  • Subject: Article
    mesheuropmc: food and beverages | parasitic diseases

Cinnamate-4-hydroxylase (C4H) converts trans-cinnamic acid (CA) to p-coumaric acid (COA) in the phenylpropanoid/lignin biosynthesis pathway. Earlier we reported increased expression of AaCYP71AV1 (an important gene of artemisinin biosynthesis pathway) caused by CA treat... View more
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