publication . Article . Other literature type . 2001

Sympathetic stimulation produces a greater increase in both transmural and spatial dispersion of repolarization in LQT1 than LQT2 forms of congenital long QT syndrome.

Kazufumi Nakamura; Masashi Inagaki; Noritoshi Nagaya; Atsushi Taguchi; Jeffrey A. Towbin; Silvia G. Priori; Wataru Shimizu; Kazuhiro Suyama; Tohru Ohe; Yasuko Tanabe; ...
Open Access English
  • Published: 01 Mar 2001 Journal: Journal of the American College of Cardiology, issue 3, pages 911-919 (issn: 07351097, Copyright policy)
  • Publisher: American College of Cardiology. Published by Elsevier Inc.
Abstract
Abstract OBJECTIVES The study compared the influence of sympathetic stimulation on transmural and spatial dispersion of repolarization between LQT1 and LQT2 forms of congenital long QT syndrome (LQTS). BACKGROUND Cardiac events are more associated with sympathetic stimulation in LQT1 than in LQT2 or LQT3 syndrome. Experimental studies have suggested that the interval between Tpeak and Tend (Tp-e) in the electrocardiogram (ECG) reflects transmural dispersion of repolarization across the ventricular wall. METHODS We recorded 87-lead body-surface ECGs before and after epinephrine infusion (0.1 μg/kg/min) in 13 LQT1, 6 LQT2, and 7 control patients. The Q-Tend (QT-e)...
Subjects
Medical Subject Headings: congenital, hereditary, and neonatal diseases and abnormalitiescardiovascular diseasescardiovascular systemcirculatory and respiratory physiology
free text keywords: Cardiology and Cardiovascular Medicine, QT interval, Stimulation, Heart block, medicine.disease, medicine, Epinephrine, medicine.drug, business.industry, business, Repolarization, Anesthesia, Sympathetic nervous system, medicine.anatomical_structure, Heart disease, Electrocardiography, medicine.diagnostic_test
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