Increased Muscular 5α-Dihydrotestosterone in Response to Resistance Training Relates to Skeletal Muscle Mass and Glucose Metabolism in Type 2 Diabetic Rats

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Horii, Naoki ; Sato, Koji ; Mesaki, Noboru ; Iemitsu, Motoyuki (2016)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 11, issue 11, page e0165689 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0165689, pmc: PMC5104401
  • Subject: Research Article | Insulin | Androgens | Anatomy | Hormones | Exercise | Diabetes Mellitus | Gastrocnemius Muscles | Endocrine Disorders | Sports Science | Muscles | Public and Occupational Health | Physical Fitness | Steroid Hormones | Lipid Hormones | Skeletal Muscles | Strength Training | Metabolic Disorders | Biology and Life Sciences | Testosterone | Musculoskeletal System | Medicine | Physical Activity | Q | R | Type 2 Diabetes | Sports and Exercise Medicine | Science | Biochemistry | Medicine and Health Sciences | Diabetic Endocrinology | Endocrinology

Regular resistance exercise induces skeletal muscle hypertrophy and improvement of glycemic control in type 2 diabetes patients. Administration of dehydroepiandrosterone (DHEA), a sex steroid hormone precursor, increases 5α-dihydrotestosterone (DHT) synthesis and is ass... View more
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