Intrathecal IgG Synthesis: A Resistant and Valuable Target for Future Multiple Sclerosis Treatments

Article, Review English OPEN
Bonnan, Mickael;
  • Publisher: Hindawi Publishing Corporation
  • Journal: Multiple Sclerosis International,volume 2,015 (issn: 2090-2654, eissn: 2090-2662)
  • Related identifiers: doi: 10.1155/2015/296184, pmc: PMC4306411
  • Subject: Review Article | Neurology. Diseases of the nervous system | RC346-429 | Article Subject

Intrathecal IgG synthesis is a key biological feature of multiple sclerosis (MS). When acquired early, it persists over time. A growing body of evidence suggests that intrathecal Ig-secreting cells may be pathogenic either by a direct action of toxic IgG or by locally s... View more
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