publication . Article . Review . 2015

Intrathecal IgG Synthesis: A Resistant and Valuable Target for Future Multiple Sclerosis Treatments

Bonnan, Mickael;
Open Access English
  • Published: 01 Jan 2015 Journal: Multiple Sclerosis International, volume 2,015 (issn: 2090-2654, eissn: 2090-2662, Copyright policy)
  • Publisher: Hindawi Limited
Abstract
Intrathecal IgG synthesis is a key biological feature of multiple sclerosis (MS). When acquired early, it persists over time. A growing body of evidence suggests that intrathecal Ig-secreting cells may be pathogenic either by a direct action of toxic IgG or by locally secreting bystander toxic products. Intrathecal IgG synthesis depends on the presence of CNS lymphoid organs, which are strongly linked at anatomical level to cortical subpial lesions and at clinical level to the impairment slope in progressive MS. As a consequence, targeting CNS lymphoid lesions could be a valuable new target in MS, especially during the progressive phase. As intrathecal IgGs are ...
Subjects
free text keywords: Review Article, Neurology. Diseases of the nervous system, RC346-429, Article Subject
155 references, page 1 of 11

Bonnan, M.. Intrathecal immune reset in multiple sclerosis: exploring a new concept. Medical Hypotheses . 2014; 82 (3): 300-309 [PubMed] [] [DOI]

Reiber, H., Ungefehr, S., Jacobi, C.. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Multiple Sclerosis . 1998; 4 (3): 111-117 [PubMed] [] [DOI]

Kostulas, V. K., Link, H., Lefvert, A. K.. Oligoclonal IgG bands in cerebrospinal fluid. Principles for demonstration and interpretation based on findings in 1114 neurological patients. Archives of Neurology . 1987; 44 (10): 1041-1044 [PubMed] [] [DOI]

Ghezzi, A., Pozzilli, C., Liguori, M.. Prospective study of multiple sclerosis with early onset. Multiple Sclerosis . 2002; 8 (2): 115-118 [PubMed] [] [DOI]

Pohl, D., Rostasy, K., Reiber, H., Hanefeld, F.. CSF characteristics in early-onset multiple sclerosis. Neurology . 2004; 63 (10): 1966-1967 [PubMed] [] [DOI]

Siritho, S., Freedman, M. S.. The prognostic significance of cerebrospinal fluid in multiple sclerosis. Journal of the Neurological Sciences . 2009; 279 (1-2): 21-25 [PubMed] [] [DOI]

Zeman, A. Z. J., Kidd, D., McLean, B. N.. A study of oligoclonal band negative multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry . 1996; 60 (1): 27-30 [OpenAIRE] [] [DOI]

Sena, A., Rosado, P., Ferret-Sena, V., Coimbra, J., Schuller, E., Sindic, C. J. M.. Multiple sclerosis and intrathecal IgA synthesis. Acta Neurologica Belgica . 1997; 97 (1): 36-38 [PubMed] []

Lolli, F., Halawa, I., Link, H.. Intrathecal synthesis of IgG, IgA, IgM and IgD in untreated multiple sclerosis and controls. Acta Neurologica Scandinavica . 1989; 80 (3): 238-247 [PubMed] [] [DOI]

Goffette, S., Schluep, M., Henry, H., Duprez, T., Sindic, C. J. M.. Detection of oligoclonal free kappa chains in the absence of oligoclonal IgG in the CSF of patients with suspected multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry . 2004; 75 (2): 308-310 [OpenAIRE] [] [DOI]

Qin, Y., Duquette, P., Zhang, Y.. Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Laboratory Investigation . 2003; 83 (7): 1081-1088 [PubMed] [] [DOI]

Harp, C., Lee, J., Lambracht-Washington, D.. Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. Journal of Neuroimmunology . 2007; 183 (1-2): 189-199 [OpenAIRE] [PubMed] [] [DOI]

Walsh, M. J., Tourtellotte, W. W.. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis. The Journal of Experimental Medicine . 1986; 163 (1): 41-53 [OpenAIRE] [PubMed] [] [DOI]

Villar, L. M., Masjuan, J., González-Porqué, P.. Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis. Annals of Neurology . 2003; 53 (2): 222-226 [PubMed] [] [DOI]

Stauch, C., Reiber, H., Rauchenzauner, M.. Intrathecal IgM synthesis in pediatric MS is not a negative prognostic marker of disease progression: quantitative versus qualitative IgM analysis. Multiple Sclerosis . 2011; 17 (3): 327-334 [OpenAIRE] [PubMed] [] [DOI]

155 references, page 1 of 11
Abstract
Intrathecal IgG synthesis is a key biological feature of multiple sclerosis (MS). When acquired early, it persists over time. A growing body of evidence suggests that intrathecal Ig-secreting cells may be pathogenic either by a direct action of toxic IgG or by locally secreting bystander toxic products. Intrathecal IgG synthesis depends on the presence of CNS lymphoid organs, which are strongly linked at anatomical level to cortical subpial lesions and at clinical level to the impairment slope in progressive MS. As a consequence, targeting CNS lymphoid lesions could be a valuable new target in MS, especially during the progressive phase. As intrathecal IgGs are ...
Subjects
free text keywords: Review Article, Neurology. Diseases of the nervous system, RC346-429, Article Subject
155 references, page 1 of 11

Bonnan, M.. Intrathecal immune reset in multiple sclerosis: exploring a new concept. Medical Hypotheses . 2014; 82 (3): 300-309 [PubMed] [] [DOI]

Reiber, H., Ungefehr, S., Jacobi, C.. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Multiple Sclerosis . 1998; 4 (3): 111-117 [PubMed] [] [DOI]

Kostulas, V. K., Link, H., Lefvert, A. K.. Oligoclonal IgG bands in cerebrospinal fluid. Principles for demonstration and interpretation based on findings in 1114 neurological patients. Archives of Neurology . 1987; 44 (10): 1041-1044 [PubMed] [] [DOI]

Ghezzi, A., Pozzilli, C., Liguori, M.. Prospective study of multiple sclerosis with early onset. Multiple Sclerosis . 2002; 8 (2): 115-118 [PubMed] [] [DOI]

Pohl, D., Rostasy, K., Reiber, H., Hanefeld, F.. CSF characteristics in early-onset multiple sclerosis. Neurology . 2004; 63 (10): 1966-1967 [PubMed] [] [DOI]

Siritho, S., Freedman, M. S.. The prognostic significance of cerebrospinal fluid in multiple sclerosis. Journal of the Neurological Sciences . 2009; 279 (1-2): 21-25 [PubMed] [] [DOI]

Zeman, A. Z. J., Kidd, D., McLean, B. N.. A study of oligoclonal band negative multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry . 1996; 60 (1): 27-30 [OpenAIRE] [] [DOI]

Sena, A., Rosado, P., Ferret-Sena, V., Coimbra, J., Schuller, E., Sindic, C. J. M.. Multiple sclerosis and intrathecal IgA synthesis. Acta Neurologica Belgica . 1997; 97 (1): 36-38 [PubMed] []

Lolli, F., Halawa, I., Link, H.. Intrathecal synthesis of IgG, IgA, IgM and IgD in untreated multiple sclerosis and controls. Acta Neurologica Scandinavica . 1989; 80 (3): 238-247 [PubMed] [] [DOI]

Goffette, S., Schluep, M., Henry, H., Duprez, T., Sindic, C. J. M.. Detection of oligoclonal free kappa chains in the absence of oligoclonal IgG in the CSF of patients with suspected multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry . 2004; 75 (2): 308-310 [OpenAIRE] [] [DOI]

Qin, Y., Duquette, P., Zhang, Y.. Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Laboratory Investigation . 2003; 83 (7): 1081-1088 [PubMed] [] [DOI]

Harp, C., Lee, J., Lambracht-Washington, D.. Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. Journal of Neuroimmunology . 2007; 183 (1-2): 189-199 [OpenAIRE] [PubMed] [] [DOI]

Walsh, M. J., Tourtellotte, W. W.. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis. The Journal of Experimental Medicine . 1986; 163 (1): 41-53 [OpenAIRE] [PubMed] [] [DOI]

Villar, L. M., Masjuan, J., González-Porqué, P.. Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis. Annals of Neurology . 2003; 53 (2): 222-226 [PubMed] [] [DOI]

Stauch, C., Reiber, H., Rauchenzauner, M.. Intrathecal IgM synthesis in pediatric MS is not a negative prognostic marker of disease progression: quantitative versus qualitative IgM analysis. Multiple Sclerosis . 2011; 17 (3): 327-334 [OpenAIRE] [PubMed] [] [DOI]

155 references, page 1 of 11
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publication . Article . Review . 2015

Intrathecal IgG Synthesis: A Resistant and Valuable Target for Future Multiple Sclerosis Treatments

Bonnan, Mickael;