Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells

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Ory, B.; Moriceau, G.D.; Trichet, V.; Blanchard, F.; Berreur, M.; Rédini, F.; Rogers, M.; Heymann, D.;

We recently demonstrated original anti-tumor effects of zoledronic acid (Zol) on osteosarcoma cell lines independently of their p53 and Rb status. The present study investigated the potential Zol-resistance acquired by osteosarcoma cells after prolonged treatment. After... View more
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