IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice

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Wang, Yuanyuan ; Jiang, Xuefeng ; Zhu, Junfeng ; Dan Yue, ; Zhang, Xiaoqing ; Wang, Xiao ; You, Yong ; Wang, Biao ; Xu, Ying ; Lu, Changlong ; Sun, Xun ; Yoshikai, Yasunobu (2016)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 6 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: pmc: PMC4992961, doi: 10.1038/srep31881
  • Subject: Article

Serum level of IL-21 is increased in patients with inflammatory bowel diseases (IBD), suggesting that IL-21/IL-21 receptor (IL-21R) signaling may be involved in the pathogenesis of IBD. However, the role of IL-21/IL-21 receptor signaling plays in the pathogenesis of IBD... View more
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