Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture

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Jacobs, Claire S.; Dervan, Peter B.;

Pyrrole-imidazole (Py-Im)a hairpin polyamides are a class of small molecule DNA-minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture. Gene regulation by polyamides requires efficient cellular uptake and nuclear local... View more
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