Regulation of c-Raf Stability through the CTLH Complex

Other literature type, Article English OPEN
McTavish, Christina J.; Bérubé-Janzen, Wesley; Wang, Xu; Maitland, Matthew E. R.; Salemi, Louisa M.; Hess, David A.; Schild-Poulter, Caroline;

c-Raf is a central component of the extracellular signal-regulated kinase (ERK) pathway which is implicated in the development of many cancer types. RanBPM (Ran-Binding Protein M) was previously shown to inhibit c-Raf expression, but how this is achieved remains unclear... View more
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