Study of Statin- and Loratadine-Induced Muscle Pain Mechanisms Using Human Skeletal Muscle Cells

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Yat Hei Leung ; Jacques Turgeon ; Veronique Michaud (2017)
  • Publisher: MDPI AG
  • Journal: Pharmaceutics, volume 9, issue 4 (issn: 1999-4923, eissn: 1999-4923)
  • Related identifiers: doi: 10.3390/pharmaceutics9040042, pmc: PMC5750648
  • Subject: lactic acid | skeletal muscle cell | Article | drug-induced muscle disorders | monocarboxylate transporters | statins | loratadine | Pharmacy and materia medica | drug-transporters | MCT | RS1-441
    mesheuropmc: food and beverages | nutritional and metabolic diseases

Many drugs can cause unexpected muscle disorders, often necessitating the cessation of an effective medication. Inhibition of monocarboxylate transporters (MCTs) may potentially lead to perturbation of l-lactic acid homeostasis and muscular toxicity. Previous studies ha... View more
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