Pathways for Small Molecule Delivery to the Central Nervous System Across the Blood-Brain Barrier

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John L. Mikitsh; Ann-Marie Chacko;
  • Publisher: Libertas Academica
  • Journal: Perspectives in Medicinal Chemistry,volume 6,pages11-24 (issn: 1177-391X, eissn: 1177-391X)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.4137/PMC.S13384, pmc: PMC4064947
  • Subject: Chemistry | brain delivery | passive diffusion | R5-920 | QD1-999 | Medicine (General) | Perspective | CNS drug | efflux pumps | facilitated transport | blood-brain barrier (BBB)

The treatment of central nervous system (CNS) disease has long been difficult due to the ineffectiveness of drug delivery across the blood-brain barrier (BBB). This review summarizes important concepts of the BBB in normal versus pathophysiology and how this physical, e... View more
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