TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation

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Uciechowski , Peter; Kahmann , Laura; Plümäkers , Birgit; Malavolta , Marco; Mocchegiani , Eugenio; Dedoussis , George; Herbein , Georges; Jajte , Jolanta; Fulop , Tamas; Rink , Lothar;
(2008)
  • Publisher: Elsevier
  • Related identifiers: doi: 10.1016/j.exger.2007.11.006
  • Subject: MESH : Aged, 80 and over | Medicine | MESH : Receptors, CCR6 | MESH : Male | MESH : Receptors, CCR4 | MESH : Th1 Cells | MESH : Zinc | MESH : Lymphocyte Activation | MESH : Trace Elements | MESH : Dietary Supplements | MESH : Humans | MESH : Aging | MESH : Female | MESH : Th2 Cells | MESH : Aged | MESH : T-Lymphocyte Subsets | [ SDV.IMM ] Life Sciences [q-bio]/Immunology

International audience; Elderly subjects suffer from increased levels of activated T cells and a TH1/TH2 imbalance. Zinc deficiency of the aged is correlated with decreased cell-mediated immune responses. The association of age and zinc adjustment with the amounts of TH... View more
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