RTEL1 contributes to DNA replication and repair and telomere maintenance

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Uringa, Evert-Jan ; Lisaingo, Kathleen ; Pickett, Hilda A. ; Brind'Amour, Julie ; Rohde, Jan-Hendrik ; Zelensky, Alex ; Essers, Jeroen ; Lansdorp, Peter M. (2012)
  • Publisher: The American Society for Cell Biology
  • Journal: Molecular Biology of the Cell, volume 23, issue 14, pages 2,782-2,792 (issn: 1059-1524, eissn: 1939-4586)
  • Related identifiers: doi: 10.1091/mbc.E12-03-0179, pmc: PMC3395665
  • Subject: FANCONI-ANEMIA PROTEIN | DAMAGE | SACCHAROMYCES-CEREVISIAE | GENOMIC STABILITY | SISTER-CHROMATID EXCHANGES | UMCG Approved | MOUSE CELLS LACKING | HOMOLOGOUS RECOMBINATION | FRAGILE SITES | MAMMALIAN-CELLS | Nuclear Functions | Articles | HUMAN-CHROMOSOMES

textabstractTelomere maintenance and DNA repair are important processes that protect the genome against instability. mRtel1, an essential helicase, is a dominant factor setting telomere length in mice. In addition, mRtel1 is involved in DNA double-strand break repair. T... View more
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