Compensatory expression of human N-Acetylglucosaminyl-1-phosphotransferase subunits in mucolipidosis type III gamma

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Pohl , Sandra; Tiede , Stephan; Castrichini , Monica; Cantz , Michael; Gieselmann , Volkmar; Braulke , Thomas;
  • Publisher: Elsevier BV
  • Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,volume 1,792,issue 3,pages221-225 (issn: 0925-4439)
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  • Related identifiers: doi: 10.1016/j.bbadis.2009.01.009
  • Subject: Molecular Biology | Mannose 6-phosphate | GNPTG | Sorting of lysosomal enzymes | Molecular Medicine | Mucolipidosis type III | GlcNAc-1-phosphotransferase

International audience; The -Acetylglucosaminyl-1-phosphotransferase plays a key role in the generation of mannose 6-phosphate (M6P) recognition markers essential for efficient transport of lysosomal hydrolases to lysosomes. The phosphotransferase is composed of six sub... View more
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