Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies.

Article, Other literature type English OPEN
Joos, Charlotte; Marrama, Laurence; Polson, Hannah E J; Corre, Sandra; Diatta, Antoine-Marie; Diouf, Babacar; Trape, Jean-François; Tall, Adama; Longacre, Shirley; Perraut, Ronald;
  • Publisher: Public Library of Science
  • Journal: volume 5,issue 3eissn: 1932-6203
  • Related identifiers: pmc: PMC2845614, doi: 10.1371/journal.pone.0009871
  • Subject: [ SDV.IMM.VAC ] Life Sciences [q-bio]/Immunology/Vaccinology | Research Article | Infectious Diseases/Tropical and Travel-Associated Diseases | merozoite | clinical protection | [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology | Immunology/Immunity to Infections | Plasmodium falciparum | Immunology/Immune Response | [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology | functional assay | Infectious Diseases/Neglected Tropical Diseases | [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology

International audience; BACKGROUND: Effective vaccines to combat malaria are urgently needed, but have proved elusive in the absence of validated correlates of natural immunity. Repeated blood stage infections induce antibodies considered to be the main arbiters of prot... View more
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