Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies.

Article, Other literature type English OPEN
Joos, Charlotte; Marrama, Laurence; Polson, Hannah E. J.; Corre, Sandra; Diatta, Antoine-Marie; Diouf, Babacar; Trape, Jean-François; Tall, Adama; Longacre, Shirley; Perraut, Ronald;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 5,issue 3 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC2845614, doi: 10.1371/journal.pone.0009871
  • Subject: [ SDV.IMM.VAC ] Life Sciences [q-bio]/Immunology/Vaccinology | Research Article | Infectious Diseases/Tropical and Travel-Associated Diseases | merozoite | clinical protection | Medicine | [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology | Immunology/Immunity to Infections | Q | R | Immunology/Immune Response | Plasmodium falciparum | [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology | Science | Infectious Diseases/Neglected Tropical Diseases | functional assay | [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology

International audience; BACKGROUND: Effective vaccines to combat malaria are urgently needed, but have proved elusive in the absence of validated correlates of natural immunity. Repeated blood stage infections induce antibodies considered to be the main arbiters of prot... View more
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