Nickel-Catalyzed Reductive Transamidation of Secondary Amides with Nitroarenes

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Cheung, Chi Wai ; Ploeger, Marten Leendert ; Hu, Xile (2017)
  • Publisher: American Chemical Society (Washington)
  • Journal: volume 7, issue 10, pages 7,092-7,096 (issn: 2155-5435, eissn: 2155-5435)
  • Related identifiers: doi: 10.1021/acscatal.7b02859
  • Subject: nitroarenes | amide synthesis | reductive coupling | transamidation | nickel catalysis

Transmidation is an attractive method for amide synthesis. However, transamidation of secondary amides is challenging. Here, we describe a reductive transamidation method that employs readily available nitro(hetero)arenes as the nitrogen sources, zinc or manganese as re... View more
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