publication . Article . Other literature type . 2016

Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma

Jonas Sokolof; Kate Fife; Rainer Kunstfeld; Rogerio I. Neves; Reinhard Dummer; Aleksandar Sekulic; Scott Ernst; Ketty Peris; Axel Hauschild; Nicole Basset-Seguin; ...
Open Access
  • Published: 10 Aug 2016 Journal: The Oncologist, volume 21, pages 1,218-1,229 (issn: 1083-7159, eissn: 1549-490X, Copyright policy)
  • Publisher: Wiley
  • Country: Switzerland
Abstract
Vismodegib and sonidegib are Hedgehog pathway inhibitors (HPIs) approved for treatment of patients with advanced basal cell carcinoma. The adverse events (AEs) associated with these therapies can impact clinical outcomes as a result of decreased quality of life and treatment discontinuation. The incidence, clinical presentation, putative mechanisms, and management strategies for AEs related to administration of HPIs are described in this article.
Subjects
free text keywords: Cancer Research, Oncology, 1, 17, Melanoma and Cutaneous Malignancies, Adverse events, Management, Advanced basal cell carcinoma, Hedgehog pathway, Dermatology Clinic, 610 Medicine & health, Biphenyl compound, Vismodegib, medicine.drug, medicine, Surgery, medicine.medical_specialty, Sonidegib, chemistry.chemical_compound, chemistry, Internal medicine, Taste disorder, business.industry, business, Adverse effect, Basal cell carcinoma, medicine.disease, Hedgehog signaling pathway, Dysgeusia, medicine.symptom
Funded by
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Genetic Epidermiology of Melanoma
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01CA083115-01A2
  • Funding stream: NATIONAL CANCER INSTITUTE
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