Développement de nouvelles approches pour la synthèse des flavaglines

Doctoral thesis English OPEN
Basmadjian , Christine;
(2015)
  • Publisher: HAL CCSD
  • Subject: [ CHIM.OTHE ] Chemical Sciences/Other | Flavagline | TRPM6 | Prohibitines | Flavaglines | Nazarov reaction | Carbocationic rearrangements | Réarrangements carbocationiques | EIF4A | Chemoresistance | Chimiorésistance | Cyclopenténones | Cancer | Prohibitins

We have developed two novel methods to prepare functionalized cyclopentenones and also discovered new acid-catalyzed rearrangements of 1-styryl propargylic alcohols. This work also explored the limitations of a method for the synthesis of flavaglines reported by Bayer r... View more
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