gene therapy enhances the therapeutic efficacy of doxorubicin to combat growth of MCF-7 breast cancer cells

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Prados , Jose; Melguizo , Consolación; Rama , Ana Rosa; Ortiz , Rául; Segura , Ana; Boulaiz , Houria; Vélez , Celia; Caba , Octavio; Ramos , Juan Luís; Aránega , Antonia;
  • Publisher: Springer Verlag
  • Related identifiers: doi: 10.1007/s00280-009-1135-1
  • Subject: Cytotoxic therapy | Multicellular tumour spheroid | gene | Gene therapy | Breast cancer | Doxorubicin
    acm: ComputingMilieux_MISCELLANEOUS

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  • References (9)

    1. Brenner H, Gondos A, Arndt V (2007) Recent major progress in long-term cancer patient survival disclosed by modeled period analysis. J Clin Oncol 25:3274-3280.

    2. Moulder S, Hortobagyi GN (2008) Advances in the treatment of breast cancer. Clin Pharmacol Ther 83:26-36.

    3. Coley HM (2008) Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treat Rev 34 :378-390.

    4. Tang SC (2009) Strategies to decrease taxanes toxicities in the adjuvant treatment o f early breast cancer. Cancer Invest 27:206-214.

    5. Freund CT, Tong XW, Rowley D, Engehausen D, Frolov A, K ieback DG, Lerner SP (2003) Combination of adenovirus- mediated thymidine kinase gene therapy with cytotoxic chemotherapy in bladder cancer in vitro. Urol Oncol 21:197-205.

    6. Mavria G, Harrington KJ, Marshall CJ, Porter CD (2005) In vivo efficacy of HSV-TK transcriptionally targeted to the tumour vasculature is augmented by combination with cytotoxic chemotherapy. J Gene Med 7:263-275.

    7. Shieh GS, Shiau AL, Yo YT, Lin PR, Chang CC, Tzai TS, Wu CL (2006) Low-dose etoposide enhances telomerase-dependent adenovirus- mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model. Cancer Res 66: 9957-9966.

    8. Gopinath P, Ghosh SS (2008) Apoptotic induction with bifunctional E.coli cytosine deaminase-uracil phosphoribosyltransferase mediated suicide gene therapy is synergized by curcumin treatment in vitro. Mol Biotechnol 39:39-48.

    9. Dachs GU, Tupper J, Tozer GM (2005) From bench to bedside for gene-directed enzyme prodrug therapy of cancer. Anticancer Drugs 16:349-359.

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