Microwave synthesis, spectral, thermal and antimicrobial studies of some Ni(II) and Cu(II) Schiff base complexes

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A P Mishra ; Neha Sharma ; Rajendra K Jain (2012)
  • Publisher: Universidad de Los Andes
  • Journal: Avances en Química (issn: 1856-5301)
  • Subject: Chemistry | Biological activity | Química | QD1-999 | Departamento de Química | Hidracina del ácido isonicotínico | Actividad biológica | Revistas | Revista Avances en Química | Facultad de Ciencias | Síntesis por microondas | Análisis térmico | Artículos Científicos [Revista Avances en Química] | Thermal study | Isonicotinic acid hydrazide | Microwave synthesis

Se sintetizaron bases de Schiff bidentadas y tridentadas (NO), (ONO) a través de la reacción de condensación entre la metil-isobutilcetona y el 2-amino-4clorofonol y 2-hidroxiacetofenona con la hidracina del ácido isonicotínico. Los complejos metálicos 1:1 o 1:2 han sido preparados mediante la interacción de estas bases de Schiff y los iones Ni(II) y Cu(II). La síntesis fue realizada empleando el método convencional y el de microondas, y los productos fueron caracterizados por análisis elemental, FT-IR, UV-Vis, RES, conductancia molar, análisis térmico y difracción de rayos X. Los complejos son coloreados y estables al aire y temperatura ambiente. El comportamiento térmico de los complejos metálicos hidratados muestran una primera etapa de pérdida de agua de hidratación, seguidos de la descomposición de las moléculas de ligando en etapas subsecuentes. El análisis de los cristales del complejo [Ni(HINH)(H2O)]Cl.3H2O a = b = 13,9338Ǻ, c = 34,7975Ǻ, V= 6755, 96Ǻ3, Z = 12, Dobs = 1,2421g/cm3, Dcal 1,2847g/cm3, refleja una estructura cristalina en un sistema ortorómbico. La conductividad eléctrica de estado sólido de los complejos metálicos indica que éstos poseen una naturaleza semiconductora. Las bases de Shiff y los complejos metálicos muestran buena actividad contra bacterias Gram-positivas del tipo Staphylococcus aureus, bacterias Gram-negativas del tipo Escherichia coli y hongos del tipo Aspergillus niger y Candida albicans. Los complejos metálicos son mejores agentes antimicrobiales que las bases de Schiff. Bidentate and tridentate (NO), (ONO) Schiff bases have been synthesized by condensing methyl isobutyl ketone with 2-amino-4-chlorophenol and 2-hydroxy acetophenone with isonicotinic acid hydrazide. The 1:1 or 1:2 metal complexes have been prepared by interacting these Schiff bases with metal ions viz. Ni(II), Cu(II). These compounds have been synthesized by conventional as well as microwave methods and characterized by elemental analysis, FT-IR, UV-Vis, ESR, molar conductance, thermal analysis and X-ray diffraction. The complexes are colored and stable in air at room temperature. The thermal behavior of metal complexes shows that the hydrated complexes loses water molecules of hydration in the first step; followed by decomposition of ligand molecules in the subsequent steps. Crystal data of [Ni(HINH)(H2O)]Cl.3H2O complex a = b =13.9338Ǻ, c = 34.7975Ǻ, V = 6755.96Ǻ3, Z = 12, Dobs = 1.2421g/cm3, Dcal 1.2847g/cm3, reflect that this complex has crystallized in orthorhombic system. The solid state electrical conductivity of the metal complexes has also been measured. Solid state electrical conductivity studies reflect semiconducting nature of the complexes. The Schiff bases and metal complexes show good activity against the Gram-positive bacteria; Staphylococcus aureus and Gram-negative bacteria; Escherichia coli and fungi Aspergillus niger and Candida albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases. 77-85 apm19@rediffmail.com cuatrimestre
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