Simultaneous determination of sulfamethoxazole and trimethoprim residues on manufacturing equipment surfaces

Article Portuguese OPEN
Roberto C. Coutinho; Elder T. Barbosa; Marcelo M. Sena; Caridad Noda Pérez;
(2009)

<abstract language="eng">A cleaning validation method was developed and validated, based on swabbing sampling and simultaneous chromatographic determination of sulfamethoxazole (SMX) and trimethoprim (TMP) residues. The method presented limits of detection of 0.06 mg mL... View more