publication . Article . 2015

Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients

Middelveen, Marianne J; Bandoski, Cheryl; Burke, Jennie; Sapi, Eva; Filush, Katherine R; Wang, Yean; Franco, Agustin; Mayne, Peter J; Stricker, Raphael B;
Open Access English
  • Published: 01 Feb 2015 Journal: BMC Dermatology, volume 15, issue 1 (issn: 1471-5945, eissn: 1471-5945, Copyright policy)
  • Publisher: BioMed Central
Abstract
Background Morgellons disease (MD) is a complex skin disorder characterized by ulcerating lesions that have protruding or embedded filaments. Many clinicians refer to this condition as delusional parasitosis or delusional infestation and consider the filaments to be introduced textile fibers. In contrast, recent studies indicate that MD is a true somatic illness associated with tickborne infection, that the filaments are keratin and collagen in composition and that they result from proliferation and activation of keratinocytes and fibroblasts in the skin. Previously, spirochetes have been detected in the dermatological specimens from four MD patients, thus provi...
Subjects
free text keywords: Dermatology, Research Article, Lyme disease, Morgellons disease, Spirochetes, Dermopathy, Borrelia burgdorferi
Related Organizations
55 references, page 1 of 4

1. Savely VR, Leitao MM, Stricker RB. The mystery of Morgellons disease: Infection or delusion? Am J Clin Dermatol. 2006;7:1-5.

2. Savely G, Leitao MM. Skin lesions and crawling sensation: disease or delusion? Adv Nurse Pract. 2005;13:16-7.

3. Savely VR, Stricker RB. Morgellons disease: the mystery unfolds. Expert Rev Dermatol. 2007;2:585-91.

4. Savely VR, Stricker RB. Morgellons disease: analysis of a population with clinically confirmed microscopic subcutaneous fibers of unknown etiology. Clin Cosmet Investig Dermatol. 2010;3:67-78. [OpenAIRE]

5. Middelveen MJ, Stricker RB. Filament formation associated with spirochetal infection: A comparative approach to Morgellons disease. Clin Cosmet Investig Dermatol. 2011;4:167-77. [OpenAIRE]

6. Middelveen MJ, Mayne PJ, Kahn DG, Stricker RB. Characterization and evolution of dermal filaments from patients with Morgellons disease. Clin Cosmet Investig Dermatol. 2013;6:1-21.

7. Middelveen MJ, Burugu D, Poruri A, Burke J, Mayne PJ, Sapi E, et al. Association of spirochetal infection with Morgellons disease. F1000 Res. 2013;2:25.

8. Mayne P, English JS, Kilbane EJ, Burke JM, Middelveen MJ, Stricker RB. Morgellons: a novel dermatological perspective as the multisystem infective disease borreliosis. F1000 Res. 2013;2:118.

9. Middelveen MJ, Rasmussen EH, Kahn DG, Stricker RB. Morgellons disease: A chemical and light microscopic study. J Clin Exp Dermatol Res. 2012;3:140.

10. Shah JS, Du Cruz I, Narciso W, Lo W, Harris NS. Improved sensitivity of Lyme disease Western blots prepared with a mixture of Borrelia burgdorferi strains 297 and B31. Chronic Dis Int. 2014;1:7.

11. Bankhead T, Chaconas G. The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens. Mol Microbiol. 2007;65:1547-58.

12. Middelveen MJ, McClain SA, Bandoski C, Israel JR, Burke J, MacDonald AB, et al. Granulomatous hepatitis associated with chronic Borrelia burgdorferi infection: a case report. Research Open Access. 2014;1:875.

13. Sapi E, Kaur N, Anyanwu S, Luecke DF, Datar A, Patel S, et al. Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi. Infect Drug Resist. 2011;4:97-113. [OpenAIRE]

14. O'Rourke M, Traweger A, Lusa L, Stupica D, Maraspin V, Barrett PN, et al. Quantitative detection of Borrelia burgdorferi sensu lato in erythema migrans skin lesions using internally controlled duplex real time PCR. PLoS One. 2013;8:e63968. [OpenAIRE]

15. Margos G, Hojgaard A, Lane RS, Cornet M, Fingerle V, Rudenko N, et al. Multilocus sequence analysis of Borrelia bissettii strains from North America reveals a new Borrelia species. Borrelia kurtenbachii Ticks Tick Borne Dis. 2010;1:151-8.

55 references, page 1 of 4
Abstract
Background Morgellons disease (MD) is a complex skin disorder characterized by ulcerating lesions that have protruding or embedded filaments. Many clinicians refer to this condition as delusional parasitosis or delusional infestation and consider the filaments to be introduced textile fibers. In contrast, recent studies indicate that MD is a true somatic illness associated with tickborne infection, that the filaments are keratin and collagen in composition and that they result from proliferation and activation of keratinocytes and fibroblasts in the skin. Previously, spirochetes have been detected in the dermatological specimens from four MD patients, thus provi...
Subjects
free text keywords: Dermatology, Research Article, Lyme disease, Morgellons disease, Spirochetes, Dermopathy, Borrelia burgdorferi
Related Organizations
55 references, page 1 of 4

1. Savely VR, Leitao MM, Stricker RB. The mystery of Morgellons disease: Infection or delusion? Am J Clin Dermatol. 2006;7:1-5.

2. Savely G, Leitao MM. Skin lesions and crawling sensation: disease or delusion? Adv Nurse Pract. 2005;13:16-7.

3. Savely VR, Stricker RB. Morgellons disease: the mystery unfolds. Expert Rev Dermatol. 2007;2:585-91.

4. Savely VR, Stricker RB. Morgellons disease: analysis of a population with clinically confirmed microscopic subcutaneous fibers of unknown etiology. Clin Cosmet Investig Dermatol. 2010;3:67-78. [OpenAIRE]

5. Middelveen MJ, Stricker RB. Filament formation associated with spirochetal infection: A comparative approach to Morgellons disease. Clin Cosmet Investig Dermatol. 2011;4:167-77. [OpenAIRE]

6. Middelveen MJ, Mayne PJ, Kahn DG, Stricker RB. Characterization and evolution of dermal filaments from patients with Morgellons disease. Clin Cosmet Investig Dermatol. 2013;6:1-21.

7. Middelveen MJ, Burugu D, Poruri A, Burke J, Mayne PJ, Sapi E, et al. Association of spirochetal infection with Morgellons disease. F1000 Res. 2013;2:25.

8. Mayne P, English JS, Kilbane EJ, Burke JM, Middelveen MJ, Stricker RB. Morgellons: a novel dermatological perspective as the multisystem infective disease borreliosis. F1000 Res. 2013;2:118.

9. Middelveen MJ, Rasmussen EH, Kahn DG, Stricker RB. Morgellons disease: A chemical and light microscopic study. J Clin Exp Dermatol Res. 2012;3:140.

10. Shah JS, Du Cruz I, Narciso W, Lo W, Harris NS. Improved sensitivity of Lyme disease Western blots prepared with a mixture of Borrelia burgdorferi strains 297 and B31. Chronic Dis Int. 2014;1:7.

11. Bankhead T, Chaconas G. The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens. Mol Microbiol. 2007;65:1547-58.

12. Middelveen MJ, McClain SA, Bandoski C, Israel JR, Burke J, MacDonald AB, et al. Granulomatous hepatitis associated with chronic Borrelia burgdorferi infection: a case report. Research Open Access. 2014;1:875.

13. Sapi E, Kaur N, Anyanwu S, Luecke DF, Datar A, Patel S, et al. Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi. Infect Drug Resist. 2011;4:97-113. [OpenAIRE]

14. O'Rourke M, Traweger A, Lusa L, Stupica D, Maraspin V, Barrett PN, et al. Quantitative detection of Borrelia burgdorferi sensu lato in erythema migrans skin lesions using internally controlled duplex real time PCR. PLoS One. 2013;8:e63968. [OpenAIRE]

15. Margos G, Hojgaard A, Lane RS, Cornet M, Fingerle V, Rudenko N, et al. Multilocus sequence analysis of Borrelia bissettii strains from North America reveals a new Borrelia species. Borrelia kurtenbachii Ticks Tick Borne Dis. 2010;1:151-8.

55 references, page 1 of 4
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publication . Article . 2015

Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients

Middelveen, Marianne J; Bandoski, Cheryl; Burke, Jennie; Sapi, Eva; Filush, Katherine R; Wang, Yean; Franco, Agustin; Mayne, Peter J; Stricker, Raphael B;