Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

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Briney, Bryan; Sok, Devin; Jardine, Joseph G.; Kulp, Daniel W.; Skog, Patrick; Menis, Sergey; Jacak, Ronald; Kalyuzhniy, Oleksandr; de Val, Natalia; Sesterhenn, Fabian; Le, Khoa M.; Ramos, Alejandra; Jones, Meaghan; Saye-Francisco, Karen L.; Blane, Tanya R.; Spencer, Skye; Georgeson, Erik; Hu, Xiaozhen; Ozorowski, Gabriel; Adachi, Yumiko; Kubitz, Michael; Sarkar, Anita; Wilson, Ian A.; Ward, Andrew B.; Nemazee, David; Burton, Dennis R.; Schief, William R.;
(2016)

Summary Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This ... View more