Preexisting Antibodies to an F(ab′)2 Antibody Therapeutic and Novel Method for Immunogenicity Assessment

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Ruppel, Jane; Brady, Ann; Elliott, Rebecca; Leddy, Cecilia; Palencia, Marco; Coleman, Daniel; Couch, Jessica A.; Wakshull, Eric;
(2016)
  • Publisher: Hindawi Publishing Corporation
  • Journal: Journal of Immunology Research,volume 2,016 (issn: 2314-8861, eissn: 2314-7156)
  • Related identifiers: pmc: PMC4927981, doi: 10.1155/2016/2921758
  • Subject: Research Article | Article Subject

Anti-therapeutic antibodies (ATAs) may impact drug exposure and activity and induce immune complex mediated toxicity; therefore the accurate measurement of ATA is important for the analysis of drug safety and efficacy. Preexisting ATAs to the hinge region of anti-Delta ... View more
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