TH1/TH2 Cytokine profile in relapsing-remitting multiple sclerosis patients treated with Glatiramer acetate or Natalizumab

Article English OPEN
Oreja-Guevara, Celia; Ramos-Cejudo, Jaime; Aroeira, Luiz Stark; Chamorro, Beatriz; Diez-Tejedor, Exuperio;
(2012)

<p>Abstract</p> <p>Background</p> <p>The balance between T helper cells Th2- and Th1-related cytokines plays a key role in multiple sclerosis (MS). A shift from a Th1 towards a Th2 cytokine profile could have a beneficial effect on the clinical course of the disease. Th... View more
  • References (39)
    39 references, page 1 of 4

    1. Sospedra M, Martin R: Immunology of multiple sclerosis. Annu Rev Immunol 2005, 23:683-747.

    2. Weiner HL: Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease. Arch Neurol 2004, 61:1613-1615.

    3. Hamann I, Zipp F, Infante-Duarte C: Therapeutic targeting of chemokine signaling in Multiple Sclerosis. J Neurol Sci 2008, 274:31-38.

    4. Ubogu EE, Cossoy MB, Ransohoff RM: The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci 2006, 27:48-55.

    5. Murphy KM, Reiner SL: The lineage decisions of helper T cells. Nat Rev Immunol 2002, 2:933-944.

    6. Segal BM: Experimental autoimmune encephalomyelitis: cytokines, effector T cells, and antigen-presenting cells in a prototypical Th1- mediated autoimmune disease. Curr Allergy Asthma Rep 2003, 3:86-93.

    7. Vartanian T, Li Y, Zhao M, Stefansson K: Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol Med 1995, 1:732-743.

    8. Sharief MK, Hentges R: Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis. N Engl J Med 1991, 325:467-472.

    9. Miller A, Glass-Marmor L, Abraham M, Grossman I, Shapiro S, Galboiz Y: Biomarkers of disease activity and response to therapy in multiple sclerosis. Clin Neurol Neurosurg 2004, 106:249-254.

    10. Imitola J, Chitnis T, Khoury SJ: Cytokines in multiple sclerosis: from bench to bedside. Pharmacol Ther 2005, 106:163-177.

  • Similar Research Results (1)
  • Metrics
Share - Bookmark