Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host
Loukeris, Thanasis G.
- Publisher: Public Library of Science
(issn: 1932-6203, eissn: 1932-6203)
Malarial Parasites | Research Article | Anatomy | Parasite Groups | Proteases | Enzymes | Protozoans | Parasitic Protozoans | Epidemiology | Apicomplexa | Proteins | Animals | Sporozoites | Disease Vectors | Mosquitoes | Biology and Life Sciences | Insect Vectors | Developmental Biology | Parasitic Life Cycles | Plasmodium | Physiology | Arthropoda | Medicine | Body Fluids | Insects | Blood | Enzymology | Q | R | Hematology | Life Cycles | Science | Biochemistry | Organisms | Parasitic Diseases | Medicine and Health Sciences | Invertebrates | Parasitology
Site-2 proteases (S2P) belong to the M50 family of metalloproteases, which typically perform essential roles by mediating activation of membrane-bound transcription factors through regulated intramembrane proteolysis (RIP). Protease-dependent liberation of dormant trans...