Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host

Article English OPEN
Koussis, Konstantinos ; Goulielmaki, Evi ; Chalari, Anna ; Withers-Martinez, Chrislaine ; Siden-Kiamos, Inga ; Matuschewski, Kai ; Loukeris, Thanasis G. (2017)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 12, issue 1 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0170260, pmc: PMC5249076
  • Subject: Malarial Parasites | Research Article | Anatomy | Parasite Groups | Proteases | Enzymes | Protozoans | Parasitic Protozoans | Epidemiology | Apicomplexa | Proteins | Animals | Sporozoites | Disease Vectors | Mosquitoes | Biology and Life Sciences | Insect Vectors | Developmental Biology | Parasitic Life Cycles | Plasmodium | Physiology | Arthropoda | Medicine | Body Fluids | Insects | Blood | Enzymology | Q | R | Hematology | Life Cycles | Science | Biochemistry | Organisms | Parasitic Diseases | Medicine and Health Sciences | Invertebrates | Parasitology

Site-2 proteases (S2P) belong to the M50 family of metalloproteases, which typically perform essential roles by mediating activation of membrane-bound transcription factors through regulated intramembrane proteolysis (RIP). Protease-dependent liberation of dormant trans... View more
Share - Bookmark