Large-scale structural alteration of brain in epileptic children with SCN1A mutation

Article English OPEN
Yun-Jeong Lee; Mi-Sun Yum; Min-Jee Kim; Woo-Hyun Shim; Hee Mang Yoon; Il Han Yoo; Jiwon Lee; Byung Chan Lim; Ki Joong Kim; Tae-Sung Ko;
(2017)
  • Publisher: Elsevier
  • Journal: NeuroImage : Clinical, volume 15, pages 594-600 (issn: 2213-1582, eissn: 2213-1582)
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.1016/j.nicl.2017.06.002, pmc: PMC5479971
  • Subject: Epilepsy | R858-859.7 | WM, white matter | Magnetic resonance imaging | Computer applications to medicine. Medical informatics | Neurology. Diseases of the nervous system | RC346-429 | SMEI, severe myoclonic epilepsy of infancy | SCN1A | TIV, total intracranial volume | Surface area | CSF, cerebrospinal fluid | Brain volume | Children | Regular Article | GEFS +,  genetic epilepsy with febrile seizures plus | MRI, magnetic resonance imaging | GM, gray matter

Objective: Mutations in SCN1A gene encoding the alpha 1 subunit of the voltage gated sodium channel are associated with several epilepsy syndromes including genetic epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy of infancy (SMEI). However, in ... View more
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