publication . Article . 1995

Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective

Name: Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective
Creator: Nicholas V. Vamvakopoulos
Keywords: RB1-214, Pathology, Research Article

Nicholas V. Vamvakopoulos;

Open Access English

Published: 01 Jan 1995 Journal: Mediators of Inflammation, volume 4, issue 3, pages 163-174 (issn: 0962-9351, eissn: 1466-1861,

Publisher: Hindawi Publishing Corporation

Summary

Abstract

This review higlghts key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a proposed mechanism to account for the tissue-specific antithetical responses of hCRH gene expression to glucocorticolds, that may also explain the frequently observed antithetical effects of chronic glucocorticoid administration in clinical practice and (2) a heuristic diagram to illustrate the proposed modulation of the stress response and immune/ inflammatory reaction b...

doi: 10.1155/S0962935195000275

pmc: PMC2365637

pmid: 18475634

Subjects

mesheuropmc: endocrine systemhormones, hormone substitutes, and hormone antagonists

free text keywords: RB1-214, Pathology, Research Article

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Mediators of Inflammation

Article . 1995

Provider: DOAJ-Articles

Europe PubMed Central

Article . 1995

Provider: PubMed Central

Hindawi Publishing Corporation/ Mediators of Inflammation

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