Uncarinic Acid C Isolated from Uncaria rhynchophylla Induces Differentiation of Th1-Promoting Dendritic Cells Through TLR4 Signaling

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Kim, Kyu Sik ; Pham, Thanh Nhan Nguyen ; Jin, Chun-Ji ; Umeyama, Akemi ; Shoji, Noboru ; Hashimoto, Toshihiro ; Lee, Je-Jung ; Takei, Masao (2011)
  • Publisher: Libertas Academica
  • Journal: Biomarker Insights, volume 6, pages 27-38 (issn: 1177-2719, eissn: 1177-2719)
  • Related identifiers: doi: 10.4137/BMI.S6441, pmc: PMC3076018
  • Subject: Dendritic cells | R5-920 | Medicine (General) | Original Research | CTL | Th1 | Uncarinic acid C

Uncarinic acid C (URC) is triterpene isolated from Uncaria rhynchophylla and is a pharmacologically active substance. The induction of dendritic cells (DC) is critical for the induction of Ag-specific T lymphocyte responses and may be essential for the development of hu... View more
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