Bone Marrow-Derived Mesenchymal Stem Cells Repaired but Did Not Prevent Gentamicin-Induced Acute Kidney Injury through Paracrine Effects in Rats

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Reis, Luciana A.; Borges, Fernanda T.; Simões, Manuel J.; Borges, Andrea A.; Sinigaglia-Coimbra, Rita; Schor, Nestor;
(2012)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 7,issue 9 (eissn: 1932-6203)
  • Related identifiers: pmc: PMC3435420, doi: 10.1371/journal.pone.0044092
  • Subject: Stem Cells | Cellular Types | Research Article | Biology | Molecular Cell Biology | Immune Physiology | Developmental Biology | Adverse Reactions | Medicine | Critical Care and Emergency Medicine | Anatomy and Physiology | Nephrology | Acute Renal Failure | Drugs and Devices | Mesenchymal Stem Cells | Immune System | Cytokines | Immunology

This study evaluated the effects of bone marrow-derived mesenchymal stem cells (BMSCs) or their conditioned medium (CM) on the repair and prevention of Acute Kidney Injury (AKI) induced by gentamicin (G). Animals received daily injections of G up to 20 days. On the 10th... View more
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