A Look into the Melting Pot: The mecC-Harboring Region Is a Recombination Hot Spot in Staphylococcus stepanovicii

Article English OPEN
Semmler, Torsten; Harrison, Ewan M.; Lübke-Becker, Antina; Ulrich, Rainer G.; Wieler, Lothar H.; Guenther, Sebastian; Stamm, Ivonne; Hanssen, Anne-Merethe; Holmes, Mark A.; Vincze, Szilvia; Walther, Birgit;
  • Publisher: Public Library of Science
  • Journal: volume 11,issue 1eissn: 1932-6203
  • Related identifiers: doi: 10.1371/journal.pone.0147150, pmc: PMC4723332
  • Subject: Molecular Biology | Microbial Control | Computational Biology | VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715 | Microbial pathogens | Gene Prediction | Research Article | Bacteria | Pathology and laboratory medicine | Sequence Motif Analysis | Methicillin-resistant Staphylococcus aureus | Staphylococcus/genetics | Genetics | Pathogens | Recombination Genetic | Antimicrobial Resistance | Antibiotic Resistance | Molecular Biology Techniques | Genome Analysis | Chromosome Biology | Staphylococcus | Pharmacology | Genomics | Nucleotide Sequencing | Sequence Analysis | Staphylococcus aureus | Sequencing Techniques | Methicillin Resistance | Biology and Life Sciences | Research and Analysis Methods | Chromosomes | Microbiology | Bacterial pathogens | Genes Bacterial | Medical microbiology | Medizin | VDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Generell mikrobiologi: 472 | Cell Biology | VDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Generell immunologi: 478 | Organisms | Medicine and health sciences
    • ddc: ddc:610

Publisher's version, source: <a href=http://dx.doi.org/10.1371/journal.pone.0147150>http://dx.doi.org/10.1371/journal.pone.0147150</a>. INTRODUCTION Horizontal gene transfer (HGT) is an important driver for resistance- and virulence factor accumulation in pathoge... View more
  • References (47)
    47 references, page 1 of 5

    1. Wieler LH, Ewers C, Guenther S, Walther B, Lübke-Becker A. Methicillin-resistant staphylococci (MRS) and extended-spectrum beta-lactamases (ESBL)-producing Enterobacteriaceae in companion animals: nosocomial infections as one reason for the rising prevalence of these potential zoonotic

    2. Pinho MG, de Lencastre H, Tomasz A. An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci. Proc Natl Acad Sci USA 98. 2001; 98(19):10886- 91. doi: 10.1073/pnas.191260798

    3. Ito T, Hiramatsu K, Tomasz A, de Lencastre H, Perreten V, Holden MT, et al. Guidelines for reporting novel mecA gene homologues. Antimicrob Agents Chemother. 2012; 56(10):4997-9. doi: 10.1128/ AAC.01199-12 PMID: 22869575

    4. Shore AC, Coleman DC. Staphylococcal cassette chromosome mec: recent advances and new insights. Int J Med Microbiol. 2013; 303(6-7):350-9. doi: 10.1016/j.ijmm.2013.02.002 PMID: 23499303

    5. Arede P, Milheirico C, de Lencastre H, Oliveira DC. The anti-repressor MecR2 promotes the proteolysis of the mecA repressor and enables optimal expression of beta-lactam resistance in MRSA. PLoS pathogens. 2012; 8(7):e1002816. doi: 10.1371/journal.ppat.1002816 PMID: 22911052

    6. Becker K, Ballhausen B, Köck R, Kriegeskorte A. Methicillin resistance in Staphylococcus isolates: the "mec alphabet" with specific consideration of mecC, a mec homolog associated with zoonotic S. aureus lineages. Int J Med Microbiol. 2014; 304(7):794-804. doi: 10.1016/j.ijmm.2014.06.007 PMID: 25034857

    7. Deurenberg RH, Vink C, Oudhuis GJ, Mooij JE, Driessen C, Coppens G, et al. Different clonal complexes of methicillin-resistant Staphylococcus aureus are disseminated in the Euregio Meuse-Rhine region. Antimicrob Agents Chemother. 2005; 49(10):4263-71. PMID: 16189107

    8. Ito T, Okuma K, Ma XX, Yuzawa H, Hiramatsu K. Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC. Drug Resist Updat. 2003; 6(1):41-52. PMID: 12654286

    9. Boundy S, Safo MK, Wang L, Musayev FN, O'Farrell HC, Rife JP, et al. Characterization of the Staphylococcus aureus rRNA methyltransferase encoded by orfX, the gene containing the Staphylococcal Chromosome Cassette mec (SCCmec) insertion site. J Biol Chem. 2013; 288(1):132-40. doi: 10.1074/ jbc.M112.385138 PMID: 23150671

    10. Hanssen AM, Ericson Sollid JU. SCCmec in staphylococci: genes on the move. FEMS Immunol Med Microbiol. 2006; 46(1):8-20. doi: 10.1111/j.1574-695X.2005.00009.x PMID: 16420592

  • Related Research Results (4)
  • Metrics
    No metrics available
Share - Bookmark