publication . Other literature type . Article . 2013

Fatty Acid and Phytosterol Content of Commercial Saw Palmetto Supplements

Penugonda, Kavitha; Lindshield, Brian L.;
Open Access English
  • Published: 01 Sep 2013 Journal: Nutrients, volume 5, issue 9, pages 3,617-3,633 (issn: 2072-6643, eissn: 2072-6643, Copyright policy)
  • Publisher: Multidisciplinary Digital Publishing Institute
Abstract
Saw palmetto supplements are one of the most commonly consumed supplements by men with prostate cancer and/or benign prostatic hyperplasia (BPH). Some studies have found significant improvements in BPH and lower urinary tract symptoms (LUTS) with saw palmetto supplementation, whereas others found no benefits. The variation in the efficacy in these trials may be a result of differences in the putative active components, fatty acids and phytosterols, of the saw palmetto supplements. To this end, we quantified the major fatty acids (laurate, myristate, palmitate, stearate, oleate, linoleate) and phytosterols (campesterol, stigmasterol, β-sitosterol) in 20 commercia...
Subjects
free text keywords: Nutrition. Foods and food supply, supplements, saw palmetto, prostate cancer, TX341-641, phytosterols, fatty acids, prostate, serenoa repens, Article, benign prostatic hyperplasia
50 references, page 1 of 4

1. Barnes, P.M.; Bloom, B.; Nahin, R.L. Complementary and Alternative Medicine Use among Adults and Children: United States, 2007; CDC National Health Statistics Report: Hyattsville, MD, USA, December 2008; pp. 1-23.

2. Blumenthal, M.; Lindstrom, A.; Ooyen, C.; Lynch, M.E. Herb supplement sales increase 4.5% in 2011, despite still-weak economy, herb sales continue multi-year growth. HerbalGram 2012, 95, 60-64.

3. Bishop, F.L.; Rea, A.; Lewith, H.; Chan, Y.K.; Saville, J.; Prescott, P.; von Elm, E.; Lewith, G.T. Complementary medicine use by men with prostate cancer: A systematic review of prevalence studies. Prostate Cancer Prostatic Dis. 2011, 14, 1-13.

4. Bauer, C.; Ishak, M.; Johnson, E.; Beebe Dimmer, J.; Cooney, K. Prevalence and correlates of vitamin and supplement usage among men with a family history of prostate cancer. Integr. Cancer Ther. 2012, 11, 83-89.

5. Iehlé, C.; Délos, S.; Guirou, O.; Tate, R.; Raynaud, J.P.; Martin, P.M. Human prostatic steroid 5α-reductase isoforms-A comparative study of selective inhibitors. J. Steroid Biochem. Mol. Biol. 1995, 54, 273-279.

6. Bayne, C.W.; Donnelly, F.; Ross, M.; Habib, F.K. Serenoa repens (Permixon): A 5α-reductase types I and II inhibitor-New evidence in a coculture model of BPH. Prostate 1999, 40, 232-241.

7. Bayne, C.W.; Ross, M.; Donnelly, F.; Habib, F.K. The selectivity and specificity of the actions of the lipido-sterolic extract of Serenoa repens (Permixon) on the prostate. J. Urol. 2000, 164, 876-881.

8. Habib, F.K.; Ross, M.; Ho, C.K.H.; Lyons, V.; Chapman, K. Serenoa repens (permixon) inhibits the 5α-reductase activity of human prostate cancer cell lines without interfering with PSA expression. Int. J. Cancer 2005, 114, 190-194.

9. Anderson, M.L. A preliminary investigation of the enzymatic inhibition of 5α-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro. J. Herbal Pharmacother. 2005, 5, 17-26.

10. Pais, P. Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5α-reductase II. Adv. Ther. 2010, 27, 555-563.

11. Van Coppenolle, F.; Le Bourhis, X.; Carpentier, F.; Delaby, G.; Cousse, H.; Raynaud, J.P.; Dupouy, J.P.; Prevarskaya, N. Pharmacological effects of the lipidosterolic extract of Serenoa repens (Permixon) on rat prostate hyperplasia induced by hyperprolactinemia: Comparison with finasteride. Prostate 2000, 43, 49-58.

12. Talpur, N.; Echard, B.; Bagchi, D.; Bagchi, M.; Preuss, H.G. Comparison of Saw Palmetto (extract and whole berry) and Cernitin on prostate growth in rats. Mol. Cell. Biochem. 2003, 250, 21-26.

13. Carbajal, D.; Molina, V.; Mas, R.; Arruzazabala, M.L. Therapeutic effect of D-004, a lipid extract from Roystonea regia fruits, on prostate hyperplasia induced in rats. Drugs Exp. Clin. Res. 2005, 31, 193-197.

14. Wadsworth, T.L.; Worstell, T.R.; Greenberg, N.M.; Roselli, C.E. Effects of dietary saw palmetto on the prostate of transgenic adenocarcinoma of the mouse prostate model (TRAMP). Prostate 2007, 67, 661-673.

15. Arruzazabala, M.L.; Molina, V.; Mas, R.; Carbajal, D.; Marrero, D.; González, V.; Más, R.; Rodríguez, E. Effects of coconut oil on testosterone-induced prostatic hyperplasia in Sprague-Dawley rats. J. Pharm. Pharmacol. 2007, 59, 995-999.

50 references, page 1 of 4
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2013

Fatty Acid and Phytosterol Content of Commercial Saw Palmetto Supplements

Penugonda, Kavitha; Lindshield, Brian L.;