Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals

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Maija Pihlajamäki; Reisa A. Sperling;
  • Publisher: IOS Press
  • Journal: Behavioural Neurology,volume 21,issue 1-2,pages77-91 (issn: 0953-4180, eissn: 1875-8584)
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  • Related identifiers: doi: 10.3233/BEN-2009-0231., doi: 10.3233/BEN-2009-0231, pmc: PMC5450588
  • Subject: memory | Research Article | Neurosciences. Biological psychiatry. Neuropsychiatry | RC321-571 | posterior cingulate cortex | precuneus | task-induced deactivation | apolipoprotein E | Aging | Alzheimer's disease (AD) | default mode network | functional magnetic resonance imaging (fMRI) | mild cognitive impairment (MCI)

Alzheimer’s disease (AD) is the most common form of dementia in old age, and is characterized by prominent impairment of episodic memory. Recent functional imaging studies in AD have demonstrated alterations in a distributed network of brain regions supporting memory fu... View more
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