Chronic Insulin Exposure Induces ER Stress and Lipid Body Accumulation in Mast Cells at the Expense of Their Secretory Degranulation Response.

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Greineisen, William E.; Maaetoft-Udsen, Kristina; Speck, Mark; Balajadia, Januaria; Shimoda, Lori M. N.; Sung, Carl; Turner, Helen;

Lipid bodies (LB) are reservoirs of precursors to inflammatory lipid mediators in immunocytes, including mast cells. LB numbers are dynamic, increasing dramatically under conditions of immunological challenge. We have previously shown in vitro that insulin-influenced li... View more