Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

Article, Other literature type English OPEN
Brochard, Vanessa; Combadière, Béhazine; Prigent, Annick; Laouar, Yasmina; Perrin, Aline; Beray-Berthat, Virginie; Bonduelle, Olivia; Alvarez-Fischer, Daniel; Callebert, Jacques; Launay, Jean-Marie; Duyckaerts, Charles; Flavell, Richard,; Hirsch, Etienne,; Hunot, Stéphane;
(2008)
  • Publisher: American Society for Clinical Investigation
  • Related identifiers: pmc: PMC2613467, doi: 10.1172/JCI36470
  • Subject: MESH: Male | MESH: Disease Models, Animal | [ SDV.IMM.IA ] Life Sciences [q-bio]/Immunology/Adaptive immunology | [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] | MESH : Animals | adaptive immunity | MESH : Male | [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology | MESH: Mice, Inbred C57BL | [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology | MESH : Immune System | MESH: Dopamine | MESH : Neurons | MESH: Neurons | MESH: Nerve Degeneration | MESH : Interferon-gamma | MESH : Parkinson Disease | [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology | MESH: Mice | MESH : Fas Ligand Protein | MESH : Humans | MESH : Mice, Knockout | MESH : Aged | MESH : Cell Death | MESH : Aged, 80 and over | MESH: Animals | Research Article | MESH: Aged | MESH: Aged, 80 and over | MESH: Fas Ligand Protein | [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] | MESH: Homeodomain Proteins | MESH : Nerve Degeneration | MESH: Parkinsonian Disorders | MESH: CD4-Positive T-Lymphocytes | MESH : Disease Models, Animal | MESH : Dopamine | MESH : CD4-Positive T-Lymphocytes | MESH: Interferon-gamma | MESH: Humans | MESH : Mice, Inbred C57BL | MESH : Homeodomain Proteins | MESH : Parkinsonian Disorders | lymphocyte | MESH : Brain | MESH: Parkinson Disease | MESH: Brain | MESH: Immune System | MESH: Mice, Knockout | MESH: Cell Death | Parkinson's disease | MESH : Mice

International audience; Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system. However, the pathogenic role of the ... View more
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