Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

Article, Other literature type English OPEN
Brochard , Vanessa ; Combadière , Béhazine ; Prigent , Annick ; Laouar , Yasmina ; Perrin , Aline ; Beray-Berthat , Virginie ; Bonduelle , Olivia ; Alvarez-Fischer , Daniel ; Callebert , Jacques ; Launay , Jean-Marie ; Duyckaerts , Charles ; Flavell , Richard , ; Hirsch , Etienne , ; Hunot , Stéphane (2009)
  • Publisher: American Society for Clinical Investigation
  • Related identifiers: pmc: PMC2613467, doi: 10.1172/JCI36470
  • Subject: MESH : Aged, 80 and over | Research Article | [ SDV.IMM.IA ] Life Sciences [q-bio]/Immunology/Adaptive immunology | [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] | MESH : Animals | MESH : Nerve Degeneration | adaptive immunity | MESH : Male | [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology | MESH : Immune System | MESH : Neurons | MESH : Disease Models, Animal | MESH : Dopamine | MESH : CD4-Positive T-Lymphocytes | MESH : Mice, Inbred C57BL | MESH : Homeodomain Proteins | MESH : Parkinsonian Disorders | lymphocyte | MESH : Interferon-gamma | MESH : Parkinson Disease | MESH : Brain | MESH : Fas Ligand Protein | MESH : Humans | MESH : Mice, Knockout | MESH : Aged | MESH : Cell Death | Parkinson's disease | MESH : Mice

International audience; Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system. However, the pathogenic role of the ... View more
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