publication . Other literature type . Article . 2012

A structured approach to the study of metabolic control principles in intact and impaired mitochondria

Huber, Heinrich J; Connolly, Niamh MC; Düssmann, Heiko; Prehn, Jochen HM;
Open Access English
  • Published: 01 Mar 2012 Journal: Molecular BioSystems, volume 8, issue 3, page 828 (issn: 1742-206X 1742-2051, eissn: 1742-2051, Copyright policy)
  • Publisher: e-publications@RCSI
Abstract
We devised an approach to extract control principles of cellular bioenergetics for intact and impaired mitochondria from ODE-based models and applied it to a recently established bioenergetic model of cancer cells. The approach used two methods for varying ODE model parameters to determine those model components that, either alone or in combination with other components, most decisively regulated bioenergetic state variables. We found that, while polarisation of the mitochondrial membrane potential (ΔΨ(m)) and, therefore, the protomotive force were critically determined by respiratory complex I activity in healthy mitochondria, complex III activity was dominant ...
Subjects
free text keywords: Cell Respiration, Oxygen Consumption, Mitochondria, Adenosine Triphosphate, Cytochromes c, Membrane Potential, Physics, Physiology, Mitochondrial, Membrane Potential, Mitochondrial, Energy Metabolism
Funded by
EC| APO-SYS
Project
APO-SYS
Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine
  • Funder: European Commission (EC)
  • Project Code: 200767
  • Funding stream: FP7 | SP1 | HEALTH
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publication . Other literature type . Article . 2012

A structured approach to the study of metabolic control principles in intact and impaired mitochondria

Huber, Heinrich J; Connolly, Niamh MC; Düssmann, Heiko; Prehn, Jochen HM;