Synthesis of chiral N-phosphinyl α-imino esters and their application in asymmetric synthesis of α-amino esters by reduction

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Xiong, Yiwen; Mei, Haibo; Wu, Lingmin; Han, Jianlin; Pan, Yi; Li, Guigen;
  • Publisher: Beilstein-Institut
  • Journal: Beilstein Journal of Organic Chemistry,volume 10,pages653-659 (issn: 1860-5397, eissn: 1860-5397)
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  • Related identifiers: pmc: PMC3999852, doi: 10.3762/bjoc.10.57
  • Subject: Chemistry | phosphinyl auxiliary | Full Research Paper | Q | α-imino ester | Organic chemistry | QD241-441 | group-assisted purification | Science | reduction | α-amino ester

Summary A variety of chiral N-phosphinyl α-imino esters have been synthesized for the first time from ketoesters and phosphinylamide, which were then reduced by L-selectride to give the corresponding N-phosphinyl-protected α-amino esters. The reduction proceeded very we... View more
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