A Network Approach of Gene Co-expression in the Zea mays/Aspergillus flavus Pathosystem to Map Host/Pathogen Interaction Pathways

Article English OPEN
Musungu, Bryan M.; Bhatnagar, Deepak; Brown, Robert L.; Payne, Gary A.; OBrian, Greg; Fakhoury, Ahmad M.; Geisler, Matt;
(2016)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Genetics,volume 7 (issn: 1664-8021, eissn: 1664-8021)
  • Related identifiers: pmc: PMC5116468, doi: 10.3389/fgene.2016.00206
  • Subject: Genetics | RNA-sequencing | Aspergillus flavus | gene co-expression analysis | Zea mays | Original Research | networks
    mesheuropmc: food and beverages | heterocyclic compounds

A gene co-expression network (GEN) was generated using a dual RNA-seq study with the fungal pathogen Aspergillus flavus and its plant host Zea mays during the initial 3 days of infection. The analysis deciphered novel pathways and mapped genes of interest in both organi... View more
  • References (86)
    86 references, page 1 of 9

    Abdel-Hadi A. Schmidt-Heydt M. Parra R. Geisen R. Magan N. (2012). A systems approach to model the relationship between aflatoxin gene cluster expression, environmental factors, growth and toxin production by Aspergillus flavus. J. R. Soc. Interface 9 757–767. 10.1098/rsif.2011.0482

    Amare M. G. Keller N. P. (2014). Molecular mechanisms of Aspergillus flavus secondary metabolism and development. Fungal Genet. Biol. 66 11–18. 10.1016/j.fgb.2014.02.008

    Bader G. D. Hogue C. W. (2003). An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics 4:1. 10.1186/1471-2105-4-1

    Bhardwaj N. Lu H. (2005). Correlation between gene expression profiles and protein–protein interactions within and across genomes. Bioinformatics 21 2730–2738. 10.1093/bioinformatics/bti398

    Borad V. Sriram S. (2008). Pathogenesis-related proteins for the plant protection. Asian J. Exp. Sci. 22 189–196.

    Burow G. B. Nesbitt T. C. Dunlap J. Keller N. P. (1997). Seed lipoxygenase products modulate Aspergillus mycotoxin biosynthesis. Mol. Plant Microbe Interact. 10 380–387. 10.1094/MPMI.1997.10.3.380

    Carlson M. R. Zhang B. Fang Z. Mischel P. S. Horvath S. Nelson S. F. (2006). Gene connectivity, function, and sequence conservation: predictions from modular yeast coexpression networks. BMC Genomics 7:1. 10.1186/1471-2164-7-1

    Carrera J. Rodrigo G. Jaramillo A. Elena S. F. (2009). Reverse-engineering the Arabidopsis thaliana transcriptional network under changing environmental conditions. Genome Biol. 10:R96. 10.1186/gb-2009-10-9-r96

    Chanda A. Roze L. V. Linz J. E. (2010). A possible role for exocytosis in aflatoxin export in Aspergillus parasiticus. Eukaryot. Cell 9 1724–1727. 10.1128/EC.00118-10

    Chang P.-K. Ehrlich K. C. Yu J. Bhatnagar D. Cleveland T. E. (1995). Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis. Appl. Environ. Microbiol. 61 2372–2377.

  • Related Research Results (2)
  • Metrics
    No metrics available
Share - Bookmark