Model-based investigation of the circadian clock and cell cycle coupling in mouse embryonic fibroblasts: Prediction of RevErb-α up-regulation during mitosis

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Traynard , Pauline ; Feillet , Céline ; Soliman , Sylvain ; Delaunay , Franck ; Fages , François (2016)
  • Publisher: Elsevier
  • Related identifiers: doi: 10.1016/j.biosystems.2016.07.003
  • Subject: Data fitting | Model Checking | Cell cycle | Formal methods | Model coupling | Quantitative biology | Oscillations | Circadian clock | [ INFO.INFO-BI ] Computer Science [cs]/Bioinformatics [q-bio.QM]

International audience; Experimental observations have put in evidence autonomous self-sustained circadian oscillators in most mammalian cells, and proved the existence of molecular links between the circadian clock and the cell cycle. Some mathematical models have also... View more
  • References (20)
    20 references, page 1 of 2

    [1] C. L. Partch, C. B. Green, J. S. Takahashi, Molecular architecture of the mammalian circadian clock, Trends Cell Biol. 24 (2) (2014) 90{99.

    [2] T. Matsuo, S. Yamaguchi, S. Mitsui, A. Emi, F. Shimoda, H. Okamura, Control mechanism of the circadian clock for timing of cell division in vivo, Science 302 (5643) (2003) 255{259.

    [3] J. W. Barnes, S. A. Tischkau, J. A. Barnes, J. W. Mitchell, P. W. Burgoon, J. R. Hickok, M. U. Gillette, Requirement of mammalian timeless for circadian rhythmicity, Science 302 (5644) (2003) 439{442.

    [4] K. Unsal-Kacmaz, T. E. Mullen, W. K. Kaufmann, A. Sancar, Coupling of human circadian and cell cycles by the timeless protein, Molecular and Cellular Biology 25 (8) (2005) 3109{3116.

    [5] A. Ballesta, S. Dulong, C. Abbara, B. Cohen, A. Okyar, J. Clairambault, F. Levi, A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery, PLOS Computational Biology 7 (9).

    [6] E. De Maria, F. Fages, A. Rizk, S. Soliman, Design, optimization, and predictions of a coupled model of the cell cycle, circadian clock, dna repair

    [7] E. Nagoshi, C. Saini, C. Bauer, T. Laroche, F. Naef, U. Schibler, Circadian gene expression in individual broblasts: cell-autonomous and selfsustained oscillators pass time to daughter cells., Cell 119 (2004) 693{705.

    [15] A. Relogio, P. O. Westermark, T. Wallach, K. Schellenberg, A. Kramer, H. Herzel, Tuning the mammalian circadian clock: robust synergy of two loops., PLoS computational biology 7 (12) (2011) e1002309.

    [16] Z. Qu, W. R. MacLellan, J. N. Weiss, Dynamics of the cell cycle: checkpoints, sizers, and timers, Biophysics Journal 85 (6) (2003) 3600{3611.

    [17] P. Traynard, F. Fages, S. Soliman, Model-based investigation of the e ect of the cell cycle on the circadian clock through transcription inhibition during mitosis, in: O. Roux, J. Bourdon (Eds.), CMSB'15: Proceedings of the thirteenth international conference on Computational Methods in Systems Biology, Vol. 9308 of Lecture Notes in BioInformatics, SpringerVerlag, 2015, pp. 208{221.

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